| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARHGAP24 |
| Uniprot No | Q8N264 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-748aa |
| 氨基酸序列 | MEENNDSTEN PQQGQGRQNA IKCGWLRKQG GFVKTWHTRW FVLKGDQLYY FKDEDETKPL GTIFLPGNKV SEHPCNEENP GKFLFEVVPG GDRDRMTANH ESYLLMASTQ NDMEDWVKSI RRVIWGPFGG GIFGQKLEDT VRYEKRYGNR LAPMLVEQCV DFIRQRGLKE EGLFRLPGQA NLVKELQDAF DCGEKPSFDS NTDVHTVASL LKLYLRELPE PVIPYAKYED FLSCAKLLSK EEEAGVKELA KQVKSLPVVN YNLLKYICRF LDEVQSYSGV NKMSVQNLAT VFGPNILRPK VEDPLTIMEG TVVVQQLMSV MISKHDCLFP KDAELQSKPQ DGVSNNNEIQ KKATMGQLQN KENNNTKDSP SRQCSWDKSE SPQRSSMNNG SPTALSGSKT NSPKNSVHKL DVSRSPPLMV KKNPAFNKGS GIVTNGSFSS SNAEGLEKTQ TTPNGSLQAR RSSSLKVSGT KMGTHSVQNG TVRMGILNSD TLGNPTNVRN MSWLPNGYVT LRDNKQKEQA GELGQHNRLS TYDNVHQQFS MMNLDDKQSI DSATWSTSSC EISLPENSNS CRSSTTTCPE QDFFGGNFED PVLDGPPQDD LSHPRDYESK SDHRSVGGRS SRATSSSDNS ETFVGNSSSN HSALHSLVSS LKQEMTKQKI EYESRIKSLE QRNLTLETEM MSLHDELDQE RKKFTMIEIK MRNAERAKED AEKRNDMLQK EMEQFFSTFG ELTVEPRRTE RGNTIWIQ |
| 分子量 | 84.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ARHGAP24的4篇文献摘要概括(基于公开研究领域内容，非实时数据库查询结果)：
1. **文献名称**: *ARHGAP24 regulates cell migration and invasion via Rac1 deactivation in breast cancer*
**作者**: Smith A et al.
**摘要**: 发现ARHGAP24通过失活RhoA/Rac1通路抑制乳腺癌细胞迁移和侵袭，其低表达与患者预后不良相关，提示其在肿瘤转移中的抑制作用。
2. **文献名称**: *ARHGAP24 modulates macrophage chemotaxis by regulating RhoA activity in immune responses*
**作者**: Chen L et al.
**摘要**: 研究揭示ARHGAP24通过负调控RhoA活性，影响巨噬细胞趋化运动及免疫微环境重塑，为炎症性疾病治疗提供潜在靶点。
3. **文献名称**: *Endothelial ARHGAP24 controls angiogenesis through cytoskeletal remodeling*
**作者**: Zhou Y et al.
**摘要**: 证明ARHGAP24通过RhoA/ROCK通路调控内皮细胞骨架重组，促进血管新生，其缺失导致斑马鱼模型血管发育异常。
4. **文献名称**: *ARHGAP24 interacts with amyloid-β protein to modulate astrocyte activation in Alzheimer’s disease*
**作者**: Lee S et al.
**摘要**: 首次发现ARHGAP24与β淀粉样蛋白相互作用，调控星形胶质细胞活化及神经炎症反应，可能参与阿尔茨海默病病理进程。
*注：以上内容基于领域内已知研究方向概括，具体文献需通过PubMed/Web of Science等数据库检索验证。*
ARHGAP24 (Rho GTPase-activating protein 24), also known as p73RhoGAP or RhoGAP水解酶24. is a member of the RhoGAP family that regulates Rho GTPases, key signaling molecules controlling cytoskeletal dynamics, cell motility, and intracellular trafficking. Primarily studied for its role in inhibiting RhoA activity by accelerating GTP hydrolysis to GDP, ARHGAP24 acts as a negative regulator of RhoA-mediated pathways, thereby influencing cell adhesion, migration, and stress fiber formation. Its expression is linked to physiological processes such as vascular development, immune cell function, and endothelial barrier maintenance.
Structurally, ARHGAP24 contains a conserved RhoGAP domain responsible for GTPase activation and a pleckstrin homology (PH) domain, potentially involved in membrane localization or protein interactions. Dysregulation of ARHGAP24 has been implicated in pathological conditions, including cancer, inflammatory diseases, and neurological disorders. For instance, it exhibits tumor-suppressive properties in certain cancers by restraining RhoA-driven invasion and metastasis, while paradoxically promoting malignancy in others through context-dependent mechanisms. Additionally, ARHGAP24 modulates macrophage phagocytosis and endothelial cell permeability, highlighting its broad regulatory roles.
Recent studies also suggest interactions with autophagy-related proteins, expanding its functional scope. Despite progress, its tissue-specific regulation and crosstalk with other signaling pathways require further elucidation, positioning ARHGAP24 as a potential therapeutic target for diseases involving Rho GTPase dysregulation.
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