| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARPM2 |
| Uniprot No | Q8TDY3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-377aa |
| 氨基酸序列 | MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE ANQKKYFVGE EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV KPSDQPLLAT EPSLNPRENR EKMAEVMFEN FGVPAFYLSD QAVLALYASA CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT KLHVAGRDIT ELLMQLLLAS GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR EYKLPDGNII SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWVT AADFKEFGTS VVQRRCF |
| 分子量 | 41 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ARPM2蛋白的假设性参考文献(注意：ARPM2名称可能需要核实，建议通过专业数据库验证信息准确性)：
1. **文献名称**：**"Efficient Expression and Purification of Recombinant Human ARPM2 in Escherichia coli"**
**作者**：Zhang et al. (2020)
**摘要**：本研究报道了一种利用大肠杆菌系统高效表达和纯化重组人ARPM2蛋白的方法。通过密码子优化和诱导条件调控，蛋白产量显著提高，并验证了其生物活性。
2. **文献名称**：**"Functional Characterization of ARPM2 in Cellular Cytoskeletal Dynamics"**
**作者**：Lee et al. (2018)
**摘要**：文章探讨了ARPM2与肌动蛋白的相互作用机制，发现其通过调控细胞骨架重组影响细胞迁移和形态，为疾病相关研究提供了新方向。
3. **文献名称**：**"Structural Insights into Human ARPM2 by X-ray Crystallography"**
**作者**：Wang et al. (2021)
**摘要**：首次解析了ARPM2蛋白的晶体结构，揭示其功能性结构域(如PDZ结构域)的关键结合位点，为靶向药物设计奠定基础。
4. **文献名称**：**"ARPM2 Dysregulation in Neurodegenerative Disorders: A Recombinant Protein-Based Study"**
**作者**：Smith et al. (2019)
**摘要**：通过重组ARPM2蛋白模型，分析了其在阿尔茨海默病中的异常表达，提示其可能作为神经退行性疾病的潜在生物标志物。
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**注意**：以上内容为示例性文献，实际研究中需通过**PubMed**或**UniProt**等平台验证ARPM2蛋白的名称及文献信息。若文献不足，建议拓展关键词(如基因别名、功能描述等)。
Here’s a concise overview of recombinant human ARPM2 protein in natural English:
Recombinant human ARPM2 (ADP-Ribosylarginine Phosphatase Member 2), also known as ADPRS, is a protein encoded by the *ADPRS* gene in humans. It belongs to the ADP-ribosylarginine hydrolase family and plays a critical role in regulating ADP-ribosylation, a post-translational modification involved in diverse cellular processes. ARPM2 specifically catalyzes the hydrolysis of ADP-ribose-arginine bonds, reversing the transfer of ADP-ribose moieties to arginine residues in target proteins. This enzymatic activity is essential for maintaining cellular homeostasis, DNA repair mechanisms, and signal transduction pathways.
Research suggests ARPM2 participates in redox regulation and stress response systems. Its dysfunction has been tentatively linked to neurological disorders and certain cancers, though mechanistic details remain under investigation. Recombinant forms of ARPM2 are typically produced using expression systems like *E. coli* or mammalian cell cultures, enabling biochemical studies and structural characterization. The recombinant protein serves as a valuable tool for exploring ADP-ribosylation dynamics, developing enzyme activity assays, and screening potential therapeutic modulators. Current studies focus on clarifying its substrate specificity, interaction partners, and regulatory networks within cellular stress adaptation and epigenetic modulation pathways.
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