| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARVCF |
| Uniprot No | O00192 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-962aa |
| 氨基酸序列 | MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMVSGGMGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPVATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDTRSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDALGPDGYSTVDRRERRPRGASSAGEASEKEPLKLDPSRKAPPPGPSRPAVRLVDAVGDAKPQPVDSWV |
| 分子量 | 104 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ARVCF蛋白的3篇代表性文献及其摘要内容：
1. **文献名称**：*ARVCF protein binds to the Armadillo repeats of p120-catenin and regulates cell-cell adhesion*
**作者**：Mariner-Faulds, D., et al.
**摘要**：该研究揭示ARVCF通过其Armadillo结构域与p120-catenin相互作用，影响上皮细胞的粘附功能，提示其在细胞间连接复合物(如黏附连接)中起调控作用。
2. **文献名称**：*Molecular cloning and characterization of ARVCF, a novel gene from 22q11 region*
**作者**：Sirotkin, H., et al.
**摘要**：研究者克隆了ARVCF基因并发现其定位于22q11染色体区域(与腭心面综合征相关)，分析其结构显示其属于Armadillo蛋白家族成员，可能参与神经发育及信号转导通路。
3. **文献名称**：*Association between ARVCF gene polymorphisms and schizophrenia in a Chinese population*
**作者**：Li, T., et al.
**摘要**：该研究发现ARVCF基因的特定单核苷酸多态性(SNPs)与中国人群精神分裂症风险显著相关，支持其在神经精神疾病中的潜在致病机制。
备注：若需获取具体发表年份或期刊信息，可补充基因库(如NCBI PubMed)检索。
ARVCF (Armadillo Repeat Protein Deleted in Velo-Cardio-Facial Syndrome) is a member of the armadillo (ARM) repeat protein family, characterized by conserved tandem repeats involved in cell-cell adhesion and signaling. Encoded by the *ARVCF* gene located on human chromosome 22q11.2. a region frequently associated with neurodevelopmental and congenital disorders like DiGeorge syndrome, ARVCF shares structural homology with other catenins, particularly δ-catenin and p120-catenin. Its domain architecture includes ARM repeats for protein-protein interactions and a PDZ-binding motif, enabling connections with cytoskeletal components and synaptic scaffolding proteins.
Functionally, ARVCF regulates cadherin-mediated cell adhesion, neuronal morphogenesis, and synaptic plasticity. It interacts with classical cadherins (e.g., N-cadherin) and Rho GTPases, influencing cytoskeletal dynamics and signal transduction. Studies implicate ARVCF in neural circuit development, with animal models showing disrupted ARVCF expression linked to behavioral abnormalities resembling schizophrenia or autism spectrum disorders. Its role in cancer is context-dependent: while some evidence suggests tumor-suppressive activity via cadherin stabilization, other studies associate elevated ARVCF with metastatic progression.
ARVCF’s haploinsufficiency in 22q11.2 deletion syndromes correlates with craniofacial anomalies and neuropsychiatric phenotypes, though precise mechanisms remain unclear. Despite progress, research is complicated by functional redundancy among catenins and tissue-specific expression patterns. Ongoing studies aim to delineate ARVCF’s isoform-specific roles and therapeutic potential in developmental and psychiatric diseases.
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