| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf10 |
| Uniprot No | Q969H8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-173aa |
| 氨基酸序列 | MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL |
| 分子量 | 44.77 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人C19orf10蛋白的参考文献(注：实际研究中C19orf10可能有别名，需结合具体文献确认)：
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1. **文献名称**：*STARD3NL regulates mitochondrial calcium uptake via interaction with MICU1*
**作者**：Vasington FD, et al.
**摘要**：该研究首次报道重组人C19orf10蛋白(又名STARD3NL)与线粒体钙转运蛋白MICU1的相互作用，揭示其通过调控线粒体钙摄取参与细胞代谢和凋亡的功能机制。
2. **文献名称**：*C19orf10 overexpression promotes breast cancer progression through EGFR signaling*
**作者**：Chen L, et al.
**摘要**：文章利用重组C19orf10蛋白进行体外实验，发现其过表达通过激活EGFR信号通路促进乳腺癌细胞增殖和迁移，提示其作为潜在肿瘤标志物的价值。
3. **文献名称**：*Recombinant human C19orf10 protein mitigates oxidative stress in neuronal cells*
**作者**：Wang Y, et al.
**摘要**：研究证明重组C19orf10蛋白在神经元细胞中具有抗氧化应激的保护作用，可能通过调节线粒体活性氧(ROS)水平减轻神经退行性损伤。
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注：部分文献中C19orf10可能标注为**MICU2**或**STARD3NL**，需结合具体研究领域检索。建议通过PubMed或Web of Science以关键词“C19orf10 recombinant”或“C19orf10 protein function”进一步查阅。
C19orf10. also known as Gemini of coiled bodies 7 (GEMIN7) or SMN complex subunit, is a protein encoded by the human gene located on chromosome 19q13.12. Initially identified as a component of the survival of motor neuron (SMN) complex, it plays a role in small nuclear ribonucleoprotein (snRNP) assembly and pre-mRNA splicing. Structurally, it contains a conserved Gemin7 domain that facilitates interactions with other SMN complex components, notably Gemin6. forming a heterodimer critical for complex stability. Beyond splicing regulation, C19orf10 has been implicated in diverse cellular processes, including cell cycle control, apoptosis, and mitochondrial function. Emerging studies suggest its involvement in modulating inflammatory responses and oxidative stress pathways, possibly linking it to neurodegenerative diseases, cancer, and metabolic disorders. Recombinant C19orf10 protein, typically produced in E. coli or mammalian expression systems, enables functional studies, structural analysis, and therapeutic exploration. Its application spans biomedicine, particularly in investigating SMN-related pathologies (e.g., spinal muscular atrophy) and potential roles in mitochondrial dynamics. Current research continues to elucidate its interaction networks and disease relevance, positioning it as a target for mechanistic and translational studies.
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