| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DSCR10 |
| Uniprot No | P59022 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-87aa |
| 氨基酸序列 | MQIVQGFPAD APLCALMWTC SFLLPGLQTE TPYPCTSLCL SSSQSAHPPL PVRVFSAESG YGIPFCAEPC SRVTVCHLQA VPVCMPV |
| 分子量 | 9.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人DSCR10蛋白的假设性参考文献示例(注：以下内容为虚构，仅作格式参考)：
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1. **文献名称**：*"Expression and Purification of Recombinant Human DSCR10 Protein in a Mammalian System"*
**作者**：Chen, L., Wang, Y., & Zhou, H.
**摘要**：该研究描述了一种在哺乳动物细胞中高效表达和纯化重组人DSCR10蛋白的方法，并验证了其结构与功能完整性，为后续生物学研究提供工具。
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2. **文献名称**：*"DSCR10 Regulates Calcineurin Signaling in Neuronal Development: Insights from Recombinant Protein Studies"*
**作者**：Johnson, R.K., Müller, S., & Patel, A.
**摘要**：通过重组人DSCR10蛋白的功能实验，作者发现其通过抑制钙调磷酸酶活性影响神经突触可塑性，提示其在唐氏综合症神经病理中的潜在作用。
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3. **文献名称**：*"Proteomic Interaction Mapping of Recombinant DSCR10 Reveals Novel Binding Partners in Cardiomyocytes"*
**作者**：Gomez, E.F., Li, T., & Singh, M.
**摘要**：本文利用重组DSCR10蛋白进行免疫共沉淀实验，鉴定了心肌细胞中与之相互作用的蛋白质网络，揭示了DSCR10在心脏发育中的新功能。
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4. **文献名称**：*"Structural Analysis of Recombinant DSCR10 by X-ray Crystallography and Implications for Down Syndrome"*
**作者**：Kato, N., Suzuki, R., & Yamashita, K.
**摘要**：通过X射线晶体学解析了重组DSCR10蛋白的三维结构，发现其特定结构域在唐氏综合症相关信号通路中的关键结合位点。
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(注：以上文献为模拟生成，如需真实文献请通过PubMed或Google Scholar搜索关键词“recombinant DSCR10”或“DSCR10 protein function”。)
**Background of Recombinant Human DSCR10 Protein**
The human DSCR10 (Down Syndrome Critical Region 10) protein, encoded by the *DSCR10* gene located on chromosome 21. has drawn attention due to its potential association with Down syndrome (DS). This gene resides within the Down Syndrome Critical Region (DSCR), a chromosomal segment linked to the neurodevelopmental and physiological features of DS. DSCR10 is predicted to function as an RNA-binding protein, with studies suggesting roles in RNA metabolism, cellular stress responses, and regulation of translation. However, its exact biological mechanisms remain unclear, partly due to limited functional characterization.
Recombinant human DSCR10 protein is produced using biotechnology platforms, such as bacterial or mammalian expression systems, enabling large-scale, high-purity yields for research applications. This engineered protein retains structural and functional features of the native form, allowing scientists to explore its interactions with nucleic acids, signaling pathways, or other cellular components. Current investigations focus on clarifying its involvement in DS-associated pathologies, including intellectual disability and immune dysregulation, as well as broader roles in neurodevelopment and cancer. Further studies using recombinant DSCR10 could uncover therapeutic targets or biomarkers for DS-related conditions. The protein’s potential as a research tool underscores its significance in both basic and translational biomedical research.
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