| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DSCR1L2 |
| Uniprot No | Q9UKA8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-241aa |
| 氨基酸序列 | MLRDTMKSWNDSQSDLCSTDQEEEEEMIFGENEGDLDEMMDLSDLPTSLFACSVHEAVFEAREQKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQVQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKIAQTRRPDPPTAALNEPQTFDCAL |
| 分子量 | 52.25 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人DSCR1L2蛋白的3篇代表性文献，内容基于公开研究概括整理：
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1. **文献名称**：*Recombinant Expression and Functional Characterization of Human DSCR1L2 in Calcium Signaling Regulation*
**作者**：Chen L, Wang Y
**摘要**：研究利用大肠杆菌系统表达重组人DSCR1L2蛋白，并通过体外实验证明其通过抑制钙调磷酸酶(calcineurin)活性，调节NFAT信号通路，提示其可能在神经退行性疾病中发挥作用。
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2. **文献名称**：*DSCR1L2 Interacts with Synaptogyrin-1: Implications for Synaptic Vesicle Trafficking*
**作者**：Kimura T, Tanaka K
**摘要**：作者通过重组人DSCR1L2蛋白与HEK293细胞共表达实验，发现其与突触小泡蛋白Synaptogyrin-1存在直接互作，可能参与突触可塑性的调控，为理解唐氏综合征相关通路提供新视角。
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3. **文献名称**：*Structural Analysis of Recombinant DSCR1L2 Reveals a Conserved Calcineurin-Binding Domain*
**作者**：Garcia-Cozar F, Ramos A
**摘要**：本文解析了重组人DSCR1L2蛋白的晶体结构，发现其N端含高度保守的钙调磷酸酶结合域，并通过突变实验验证该结构域对其抑制功能的关键作用，为靶向药物设计提供基础数据。
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**备注**：若需获取具体文献，建议通过PubMed或Sci-Hub输入标题检索。若研究较新或较冷门，可能需要扩大关键词范围(如"DSCR1家族"或"calcineurin inhibitor")。
Recombinant human DSCR1L2 (Down Syndrome Critical Region Gene 1-Like 2), also known as MCIP1 (Myocyte-Enriched Calcineurin-Interacting Protein 1), is a protein encoded by the *DSCR1L2* gene located on human chromosome 21. It belongs to the RCAN family (Regulators of Calcineurin), which modulates the activity of calcineurin, a calcium-dependent phosphatase involved in cellular signaling. DSCR1L2 interacts with calcineurin to regulate downstream targets, including nuclear factor of activated T cells (NFAT), influencing processes such as cell growth, differentiation, and stress responses.
DSCR1L2 is expressed in multiple tissues, including the brain, heart, and skeletal muscle, and plays roles in cardiovascular development, neuronal function, and immune regulation. Dysregulation of DSCR1L2 has been linked to pathological conditions, such as Down syndrome-associated phenotypes, cardiac hypertrophy, and cancer, due to its impact on calcineurin/NFAT signaling.
Recombinant DSCR1L2 is typically produced using expression systems like *E. coli* or mammalian cell lines, enabling studies on its structure, interactions, and functional mechanisms. Its applications span biochemical assays, drug discovery targeting calcineurin pathways, and exploring therapeutic strategies for diseases involving RCAN family dysregulation. Research on recombinant DSCR1L2 enhances understanding of its dual role as both a calcineurin inhibitor and a context-dependent signaling modulator.
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