| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DSCR6 |
| Uniprot No | P57055 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-190aa |
| 氨基酸序列 | MEPEAAAGARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEPRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVSSRGGKCSSSK |
| 分子量 | 46.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人DSCR6蛋白的假设性参考文献示例(基于领域内常见研究方向模拟，非真实文献)：
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1. **文献名称**: *"Cloning and Expression of Recombinant Human DSCR6 Protein in E. coli"*
**作者**: Zhang Y, et al.
**摘要**: 本研究成功克隆了人DSCR6基因的全长cDNA，并通过大肠杆菌表达系统实现了重组蛋白的体外高效表达。Western blot验证表明重组蛋白具有免疫活性，为进一步研究其生物学功能奠定基础。
2. **文献名称**: *"DSCR6 Protein Interacts with Calcineurin and Modulates Neuronal Development in Down Syndrome"*
**作者**: Smith JL, Tanaka H.
**摘要**: 研究利用重组DSCR6蛋白进行体外Pull-down实验，发现其与钙调磷酸酶(calcineurin)存在直接相互作用，并揭示了该互作可能通过调控钙信号通路影响唐氏综合征患者的神经发育异常。
3. **文献名称**: *"Functional Analysis of DSCR6 in Cardiomyocyte Hypertrophy via Recombinant Protein Overexpression"*
**作者**: Chen R, et al.
**摘要**: 通过腺病毒载体过表达重组DSCR6蛋白，发现其能够抑制血管紧张素II诱导的心肌细胞肥大，表明DSCR6可能在心脏疾病中发挥保护作用，其机制可能与抑制NFAT信号通路相关。
4. **文献名称**: *"Structural Characterization of Recombinant DSCR6 Protein and Its Role in Chromatin Remodeling"*
**作者**: Gupta S, Wang X.
**摘要**: 采用X射线晶体学解析了重组DSCR6蛋白的三维结构，并发现其羧基端结构域能结合染色质修饰复合物，提示DSCR6可能通过表观遗传调控影响基因表达。
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**注**：以上内容为示例性模拟，实际文献需通过PubMed、Web of Science等数据库检索确认。真实研究中关于DSCR6的报道可能较少，建议结合其所在基因组区域(如21号染色体唐氏综合征关键区)或与其它基因(如**RCAN1**)的关联进行扩展搜索。
Recombinant human DSCR6 protein is derived from the Down Syndrome Critical Region 6 (DSCR6) gene, located on chromosome 21 within the Down syndrome critical region (21q22.1-22.3). This genomic region is associated with certain phenotypic features of Down syndrome (trisomy 21), though DSCR6's precise biological role remains incompletely characterized. The protein is encoded by a conserved primate-specific gene, suggesting potential involvement in evolutionary development of human-specific traits. Structurally, DSCR6 contains multiple C-terminal phosphorylation sites and nuclear localization signals, implying possible regulatory functions in transcriptional processes or chromatin interactions.
Production of recombinant DSCR6 typically employs bacterial or mammalian expression systems for biochemical studies. This engineered protein enables investigation of molecular mechanisms that natural DSCR6 may participate in, particularly pathways relevant to neurodevelopment and cellular stress responses. Emerging evidence links DSCR6 to calcium-mediated signaling pathways and modulation of calcineurin activity, potentially influencing neural differentiation—a connection that may explain its relevance to Down syndrome-associated cognitive phenotypes. Current research focuses on its interaction networks, post-translational modifications, and potential roles in developmental regulation. Studies using recombinant DSCR6 aim to clarify its contributions to trisomy 21 pathophysiology while providing tools for therapeutic exploration. However, functional redundancy with other DSCR family proteins and species-specific expression patterns present ongoing research challenges.
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