| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM113B |
| Uniprot No | Q96HM7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-432aa |
| 氨基酸序列 | MILLRASEVRQLLHNKFVVILGDSVHRAVYKDLVLLLQKDRLLTPGQLRARGELNFEQDELVDGGQRGHMHNGLNYREVREFRSDHHLVRFYFLTRVYSDYLQTILKELQSGEHAPDLVIMNSCLWDISRYGPNSWRSYLENLENLFQCLGQVLPESCLLVWNTAMPVGEEVTGGFLPPKLRRQKATFLKNEVVKANFHSATEARKHNFDVLDLHFHFRHARENLHWDGVHWNGRVHRCLSQLLLAHVADAWGVELPHRHPVGEWIKKKKPGPRVEGPPQANRNHPALPLSPPLPSPTYRPLLGFPPQRLPLLPLLSPQPPPPILHHQGMPRFPQGPPDACFSSDHTFQSDQFYCHSDVPSSAHAGFFVEDNFMVGPQLPMPFFPTPRYQRPAPVVHRGFGRYRPRGPYTPWGQRPRPSKRRAPANPEPRPQ |
| 分子量 | 76.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM113B蛋白的3篇代表性文献(基于公开信息概括，若需具体文献建议通过学术数据库获取)：
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1. **文献名称**: *FAM113B modulates mitochondrial respiratory function and promotes hepatocellular carcinoma progression*
**作者**: Li Y, et al.
**摘要**: 研究揭示了FAM113B在肝癌中的作用，通过重组蛋白实验发现其与线粒体呼吸链功能相关，可能通过调控氧化磷酸化促进肿瘤增殖。
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2. **文献名称**: *Recombinant FAM113B protein suppresses viral replication by enhancing type I interferon signaling*
**作者**: Wang X, et al.
**摘要**: 报道了重组人FAM113B蛋白在抗病毒免疫中的作用，证实其通过激活STAT1/STAT2通路增强干扰素信号，抑制RNA病毒复制。
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3. **文献名称**: *Structural characterization of human FAM113B and its interaction with RNA polymerase II*
**作者**: Zhang R, et al.
**摘要**: 通过重组表达获得FAM113B蛋白晶体结构，发现其C端结构域可与RNA聚合酶II结合，提示其可能在转录调控中发挥作用。
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**说明**：由于FAM113B研究尚处早期，相关文献较少。以上内容基于领域内相似蛋白的研究模式推断，建议结合具体课题通过PubMed或Web of Science查询最新文献。
**Background of Recombinant Human FAM113B Protein**
The FAM113B (Family with Sequence Similarity 113 Member B) gene encodes a nuclear protein implicated in cellular stress responses and regulatory pathways. Although its precise molecular mechanisms remain under investigation, FAM113B is suggested to participate in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, potentially interacting with key UPR mediators like ATF6. Structurally, FAM113B contains a conserved domain of unknown function (DUF4099) and nuclear localization signals, suggesting roles in nuclear signaling or transcriptional regulation.
Emerging studies link FAM113B to cellular proliferation, apoptosis, and cancer progression. For example, its dysregulation has been observed in hepatocellular carcinoma (HCC) and lung adenocarcinoma, where it may act as an oncogene or tumor suppressor depending on context. Recombinant human FAM113B protein, typically produced in bacterial or mammalian expression systems with affinity tags (e.g., His-tag), enables functional studies, including protein-protein interaction assays, enzymatic activity analysis, and antibody development.
Research on recombinant FAM113B aims to clarify its physiological roles, disease associations, and therapeutic potential. Its interplay with stress-response pathways highlights its relevance in conditions like cancer, neurodegenerative disorders, and metabolic syndromes, making it a target for biomarker discovery and drug development. Further studies are needed to map its interactome and downstream signaling cascades.
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