| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM107A |
| Uniprot No | O95990 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-144aa |
| 氨基酸序列 | MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL |
| 分子量 | 43.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人FAM107A蛋白的示例文献(注：部分内容为简化示例，请根据实际文献调整)：
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1. **文献名称**: *FAM107A regulates tumor progression through Akt/mTOR signaling*
**作者**: Li X. et al.
**摘要**: 研究证实FAM107A蛋白通过抑制Akt/mTOR通路抑制肺癌细胞增殖，重组FAM107A蛋白的体外表达显著降低肿瘤细胞的迁移能力。
2. **文献名称**: **Structural insights into FAM107A's actin-binding domain**
**作者**: Wang Y., Suzuki T.
**摘要**: 通过X射线晶体学解析重组人FAM107A蛋白结构，发现其N端结构域与细胞骨架蛋白结合，提示其在细胞形态调控中的作用。
3. **文献名称**: *FAM107A deficiency promotes prostate cancer metastasis*
**作者**: Chen L., Zhang H.
**摘要**: 动物实验表明重组FAM107A蛋白递送可逆转前列腺癌转移表型，其机制与抑制MMP-9介导的细胞外基质降解相关。
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**提示**：实际文献检索建议使用PubMed/Google Scholar，关键词 "Recombinant human FAM107A protein" 或 "FAM107A function"。该蛋白的典型研究领域包括肿瘤抑制、神经发育及染色质重塑等。
The human FAM107A (Family with sequence similarity 107 member A) protein, encoded by the FAM107A gene located on chromosome 3p21.1. has garnered attention due to its potential role in cancer and cellular regulation. Initially identified as a candidate tumor suppressor, FAM107A is frequently downregulated or deleted in various cancers, including glioblastoma, lung, and prostate cancers. This gene resides in a genomic region (3p21.3) associated with tumor suppressor clusters, and its loss correlates with poor prognosis and tumor progression. Structurally, FAM107A contains a conserved N-terminal domain of unknown function and nuclear localization signals, suggesting involvement in nuclear processes.
Studies indicate FAM107A participates in cell proliferation, differentiation, and stress responses. It interacts with cytoskeletal components and signaling pathways, such as the Akt/mTOR axis, influencing cell motility and survival. Paradoxically, some cancers exhibit FAM107A overexpression, hinting at context-dependent roles. Recombinant human FAM107A protein, produced via bacterial or mammalian expression systems, enables functional studies to unravel its molecular mechanisms. This tool has been instrumental in identifying binding partners, dissecting pathways, and exploring therapeutic potential. Current research focuses on clarifying its dual roles in tumor suppression and oncogenesis, highlighting its importance in cancer biology and precision medicine.
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