| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM166A |
| Uniprot No | Q6J272 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-317aa |
| 氨基酸序列 | MTTTQKHDLFTPEPHYVPGYAGFFPQLRYQVGNTYGRTTGQLLTDPSVQKSPCSVLSPMSKPKFIEDFSQSKPPRVPCQDLTEPYIPHYTSLKPSKNFEILGQLPPLEVDAQEPPGVENIPRQILLPAGFTPDTPHPPCPPGRKGDSRDLGHPVYGEEAWKSATPVCEAPRQHQLYHCQRDEYPPPARRQQETLDVGSFQRLPQLDHPNLIQRKAISGYAGFIPRFTWVMGLNYRDGVMQAMDEFDKSQFLFRNPHCDLGEKLPGTHWPSNHIYSSQGLIPFYMGFIPAMQDNYALTFGNSTRRAYWKEWAKRNHTL |
| 分子量 | 34.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3条关于人FAM166A蛋白的研究文献示例(文献信息为模拟创作，仅供参考)：
1. **文献名称**：FAM166A promotes hepatocellular carcinoma progression via stabilizing CDK1
**作者**：Li X, Zhang Y, et al.
**摘要**：研究发现FAM166A通过直接结合并稳定CDK1蛋白，激活肝癌细胞的细胞周期进程，促进肿瘤增殖，表明其作为潜在治疗靶点的价值。
2. **文献名称**：Interaction between FAM166A and enterovirus 71 nonstructural proteins facilitates viral replication
**作者**：Wang Q, Chen J, et al.
**摘要**：首次报道FAM166A与肠道病毒71型非结构蛋白相互作用，通过调控宿主细胞自噬通路增强病毒复制能力，揭示其在病毒感染中的作用机制。
3. **文献名称**：Crystal structure of human FAM166A reveals a conserved ubiquitin-binding domain
**作者**：Yamamoto K, Sato T, et al.
**摘要**：解析了FAM166A蛋白的晶体结构，发现其C端含有新型泛素结合结构域，通过结构生物学分析推测其可能参与泛素化信号调控。
*注：实际文献需通过PubMed、Web of Science等数据库验证。建议使用关键词"FAM166A"或"FAM166A AND recombinant"检索，重点关注其在细胞周期调控、肿瘤发生及病毒宿主互作等领域的研究。*
**Background of Recombinant Human FAM166A Protein**
Recombinant human FAM166A protein is a genetically engineered version of the FAM166A (Family with Sequence Similarity 166 Member A) protein, encoded by the *FAM166A* gene located on chromosome 9 in humans. Although its precise biological role remains under investigation, FAM166A is implicated in cellular processes such as proliferation, apoptosis, and autophagy. Structural predictions suggest it contains conserved domains potentially involved in protein-protein interactions or nucleic acid binding.
The recombinant form is typically expressed in bacterial (e.g., *E. coli*) or mammalian systems, enabling controlled production for functional studies. Researchers utilize it to explore its interaction partners, subcellular localization (e.g., nucleus or cytoplasm), and regulatory mechanisms. FAM166A has been linked to diseases, including certain cancers and neurodegenerative disorders, highlighting its potential as a biomarker or therapeutic target. Current studies focus on elucidating its role in stress responses, cell cycle regulation, and crosstalk with signaling pathways like mTOR.
Despite limited knowledge, recombinant FAM166A serves as a critical tool for dissecting its physiological and pathological functions, advancing both basic and translational research.
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