| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM198B |
| Uniprot No | Q6UWH4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-527aa |
| 氨基酸序列 | MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTACAIYLGFLVSQVGRASLQHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSKRSKPANIRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREADAVAPGYAQGANLVKIGERPWRLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSSRSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAEFIQAAAAACLSMRLAFFIFPAWEDMRVPGKCCIGHARLTWGTYQQLLKQKCWQNGRVPKPESGCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSAALAHIIQRKHDPRHLVFIDNKSFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLLQSLFLDKVYWESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE |
| 分子量 | 84.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于假设的关于重组人FAM198B蛋白的参考文献举例(注：FAM198B研究较少，部分内容可能需要进一步验证)：
1. **标题**："Recombinant Human FAM198B Promotes Angiogenesis via Regulation of VEGFR2 Signaling"
**作者**：Wang L, et al.
**摘要**：首次成功在大肠杆菌系统中重组表达人FAM198B蛋白，并发现其通过激活VEGFR2信号通路促进血管内皮细胞迁移，提示其潜在促血管生成功能。
2. **标题**："Structural Characterization of FAM198B and Its Role in Cell Proliferation"
**作者**：Chen X, et al.
**摘要**：利用哺乳动物细胞表达系统获得高纯度FAM198B重组蛋白，解析其晶体结构，发现其通过结合EGFR调控肿瘤细胞增殖。
3. **标题**："FAM198B as a Novel Biomarker in Inflammatory Diseases"
**作者**：Kim S, et al.
**摘要**：研究发现重组FAM198B蛋白在类风湿关节炎患者血清中高表达，可能通过TLR4通路参与炎症反应，提供潜在治疗靶点。
4. **标题**："Expression and Functional Analysis of FAM198B in Hepatocellular Carcinoma"
**作者**：Zhao Y, et al.
**摘要**：利用重组FAM198B蛋白验证其在肝癌组织中的高表达，体外实验表明其可通过Wnt/β-catenin通路促进肝癌细胞侵袭转移。
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**注意**：上述文献为示例性内容，实际研究中FAM198B的报道非常有限。建议通过**PubMed/Google Scholar**以"FAM198B recombinant"或"FAM198B function"为关键词检索最新文献，或关注其同源蛋白家族(如FAM198A)的相关研究。
Recombinant human FAM198B (FAM198B) is a protein encoded by the FAM198B gene, located on human chromosome 1q32.1. Although its precise biological role remains under investigation, FAM198B is hypothesized to participate in cellular processes such as signal transduction, cell cycle regulation, and extracellular matrix interactions. Structural analyses suggest it contains conserved cysteine-rich domains, potentially involved in protein-protein interactions or enzymatic activity. FAM198B expression has been detected in various tissues, including the liver, pancreas, and reproductive organs, with altered levels observed in certain cancers, metabolic disorders, and inflammatory conditions, hinting at its potential clinical relevance.
Produced via recombinant DNA technology in expression systems like E. coli or mammalian cells, recombinant FAM198B allows functional studies by providing high-purity, standardized material. Its production typically involves affinity tags (e.g., His-tag) for purification and characterization using techniques such as SDS-PAGE and mass spectrometry. Post-translational modifications, like glycosylation, may be preserved in eukaryotic expression systems to retain native activity.
Current research focuses on elucidating FAM198B's interactions with signaling pathways (e.g., TGF-β, Wnt) and its role in angiogenesis or tumor progression. It also serves as a candidate biomarker or therapeutic target, though mechanistic insights remain limited. Further studies are required to define its molecular functions and translational potential.
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