| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM9A |
| Uniprot No | Q8IZU1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-332aa |
| 氨基酸序列 | MEPVGRKRSRKAAKAQLEAQVTAAQGATKEGSGIASNFPGQPTMEPVGRKRSRKAAKAQLEAQVRAAPAKKHTGKDPVRDECEERNPFTETREEDVTDEHGEREPFAEKDEHTGIHTMKLEHIAADIKKGLAAKREMIKIDKAAYRKTKNTIERALKKKQLKRQKRDYRHTRKLLNVLKEYIAEKQKDDEAEEAEAAAAAAEAAAAAEAAAAAAEVIVVEDEEEEEKEEEEEKEEEEEEGEEEGGGEEGEEGGGGGEGEETEEEEEEEEEEEEEEQIKAFQEKQKRWQQPTGVRSWRLREMKPLLEQLLKAAKDTKDNYCIISSSEESELDN |
| 分子量 | 36.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人FAM9A蛋白相关的模拟参考文献(仅供示例参考，具体文献需通过学术数据库验证)：
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1. **文献名称**：*Characterization of Human FAM9A Protein Expression in Germ Cell Development*
**作者**：Smith J, et al.
**摘要**：研究通过重组技术表达人FAM9A蛋白，证实其在睾丸组织中的特异性高表达，并参与精子发生调控。实验表明FAM9A与减数分裂染色体重组相关蛋白存在相互作用。
2. **文献名称**：*Functional Analysis of Recombinant FAM9A in X-Chromosome Inactivation*
**作者**：Chen L, et al.
**摘要**：利用哺乳动物细胞系统成功表达重组人FAM9A蛋白，发现其可能通过调控X染色体相关基因的表观遗传修饰影响生殖细胞发育，为男性不育机制研究提供新方向。
3. **文献名称**：*Recombinant FAM9A Binds to Histone H3K4 Methyltransferase Complexes*
**作者**：Wang Y, et al.
**摘要**：通过体外Pull-down实验证实重组FAM9A蛋白与组蛋白修饰酶复合物(如MLL家族)结合，暗示其在表观遗传调控及配子形成中的作用。
4. **文献名称**：*FAM9A Mutations and Ovarian Dysfunction: Insights from Recombinant Protein Studies*
**作者**：Garcia R, et al.
**摘要**：构建FAM9A突变体重组蛋白，发现特定突变体失去与卵巢颗粒细胞关键因子的互作能力，提示FAM9A异常可能导致女性生殖功能障碍。
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**提示**：FAM9A是X染色体上FAM9基因家族成员，现有研究多集中于其在生殖系统中的表达及表观遗传调控功能。如需真实文献，建议通过PubMed或Web of Science检索关键词(如“recombinant FAM9A”或“FAM9A protein function”)。
Recombinant human FAM9A (Family with Sequence Similarity 9 Member A) protein is a biologically engineered variant of the FAM9A protein, encoded by the FAM9A gene located on the X chromosome (Xp22.2). FAM9A belongs to the cancer/testis antigen (CTA) family, characterized by restricted expression in germline cells and certain malignancies. This protein is predominantly expressed in the testes, particularly during spermatogenesis, suggesting a potential role in germ cell development or male fertility. Structurally, it contains conserved PYMP (Proline-Tyrosine-Methionine-Proline) domains, which may mediate interactions with chromatin or other proteins.
While its precise biological function remains under investigation, FAM9A has been implicated in transcriptional regulation, chromatin remodeling, or DNA repair processes. Aberrant expression of FAM9A has been observed in various cancers, including melanoma and glioblastoma, linking it to tumorigenesis or immune evasion. Its restricted normal tissue expression and tumor-specific activation make it a potential target for immunotherapy or diagnostic biomarkers.
Recombinant FAM9A is typically produced in E. coli or mammalian expression systems, enabling functional studies, antibody development, and exploration of its interactions (e.g., with histone deacetylases or other CTAs). Current research focuses on clarifying its mechanistic role in cellular pathways and validating its therapeutic relevance in cancer and fertility-related disorders.
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