关键信息
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基因名
ARMS2
- 应用
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别名
ARMS2Age-related maculopathy susceptibility Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0C7Q2
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表达区间
1-107aa
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氨基酸序列
MLRLYPGPMV TEAEGKGGPE MASLSSSVVP VSFISTLRES VLDPGVGGEG ASDKQRSKLS LSHSMIPAAK IHTELCLPAF FSPAGTQRRF QQPQHHLTLS IIHTAAR
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分子量
11.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The research on ARMS2 (Age-Related Maculopathy Susceptibility 2) recombinant protein has gained significant attention due to its association with age-related macular degeneration (AMD), a leading cause of vision loss in the elderly. ARMS2 is a gene located within the complement factor H (CFH) region on chromosome 10 and has been identified as a risk factor for AMD through various genome-wide association studies (GWAS). The protein encoded by ARMS2 is believed to play a crucial role in the regulation of inflammation and the complement cascade, processes that are pivotal in the pathogenesis of AMD. The study of ARMS2 recombinant protein is vital for understanding its function and interaction within the retinal environment, especially how it may influence the activation of the complement system and contribute to the degeneration of retinal pigment epithelium (RPE) cells. Recombinant forms of ARMS2 can be utilized to explore its molecular mechanisms, structural characteristics, and potential as a therapeutic target. The exploration of ARMS2 holds promise not only for elucidating the biological underpinnings of AMD but also for developing novel strategies to prevent or treat this debilitating condition, ultimately improving outcomes for affected individuals.
