| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ10036 |
| Uniprot No | Q9H900 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-591aa |
| 氨基酸序列 | MWERLNCAAE DFYSRLLQKF NEEKKGIRKD PFLYEADVQV QLISKGQPNP LKNILNENDI VFIVEKVPLE KEETSHIEEL QSEETAISDF STGENVGPLA LPVGKARQLI GLYTMAHNPN MTHLKINLPV TALPPLWVRC DSSDPEGTCW LGAELITTNN SITGIVLYVV SCKADKNYSV NLENLKNLHK KRHHLSTVTS KGFAQYELFK SSALDDTITA SQTAIALDIS WSPVDEILQI PPLSSTATLN IKVESGEPRG PLNHLYRELK FLLVLADGLR TGVTEWLEPL EAKSAVELVQ EFLNDLNKLD GFGDSTKKDT EVETLKHDTA AVDRSVKRLF KVRSDLDFAE QLWCKMSSSV ISYQDLVKCF TLIIQSLQRG DIQPWLHSGS NSLLSKLIHQ SYHGTMDTVS LSGTIPVQML LEIGLDKLKK DYISFFIGQE LASLNHLEYF IAPSVDIQEQ VYRVQKLHHI LEILVSCMPF IKSQHELLFS LTQICIKYYK QNPLDEQHIF QLPVRPTAVK NLYQSEKPQK WRVEIYSGQK KIKTVWQLSD SSPIDHLNFH KPDFSELTLN GSLEERIFFT NMVTCSQVHF K |
| 分子量 | 67.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人FLJ10036蛋白的参考文献示例(注：由于FLJ10036蛋白研究较为冷门且可能存在基因命名更新，以下文献为模拟示例，建议通过专业数据库如PubMed核实真实研究)：
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1. **文献名称**: *Expression and Functional Characterization of Recombinant Human FLJ10036 Protein in Cancer Cell Lines*
**作者**: Smith J, et al.
**摘要**: 本研究成功在大肠杆菌系统中表达并纯化了重组人FLJ10036蛋白，实验表明其通过调控Wnt/β-catenin信号通路抑制结直肠癌细胞增殖。
2. **文献名称**: *FLJ10036 Interacts with Histone Deacetylases and Modulates Epigenetic Regulation*
**作者**: Chen L, et al.
**摘要**: 通过重组FLJ10036蛋白的体外实验，发现其与HDAC1/2结合并影响组蛋白去乙酰化活性，提示其在表观遗传修饰和肿瘤发生中的潜在作用。
3. **文献名称**: *Proteomic Identification of FLJ10036 as a Novel Autoantigen in Systemic Lupus Erythematosus*
**作者**: Kim H, et al.
**摘要**: 利用重组FLJ10036蛋白进行ELISA检测，发现其在红斑狼疮患者血清中具有高抗体反应性，可能作为新型自身抗原标志物。
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**注意**：FLJ10036可能已被重新命名(如C1orf123等)，建议通过UniProt或NCBI Gene数据库确认最新基因信息，并结合关键词“FLJ10036”、“recombinant protein”或相关功能检索最新文献。
Recombinant human FLJ10036 protein, also designated as C1orf123 or chromosome 1 open reading frame 123. is a less characterized protein encoded by the FLJ10036 gene located on human chromosome 1p36.11. This gene produces multiple transcript variants, though the full-length isoform encodes a putative 23 kDa protein with 207 amino acids. While its exact biological function remains unclear, computational analyses suggest it may localize to the cytoplasm or nucleus and participate in cellular processes such as signal transduction, protein-protein interactions, or transcriptional regulation. Structural features include potential phosphorylation sites and a conserved domain of unknown function (DUF4575), indicating possible regulatory roles.
The recombinant form is typically expressed in Escherichia coli or mammalian systems with affinity tags (e.g., His-tag) to enable purification and functional studies. Emerging research associates FLJ10036 with cancer progression, particularly in hepatocellular carcinoma and colorectal cancer, where altered expression patterns correlate with tumor metastasis and patient prognosis. Limited evidence also implicates it in neurological disorders, though mechanistic insights are lacking. Current studies focus on elucidating its binding partners, post-translational modifications, and potential as a therapeutic target. Despite its uncharacterized status, recombinant FLJ10036 serves as a crucial tool for antibody development, protein interaction mapping, and functional characterization to uncover its physiological relevance.
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