| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FKBP9L |
| Uniprot No | Q75LS8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-142aa |
| 氨基酸序列 | MDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEAKQDEL |
| 分子量 | 42 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FKBP9L蛋白的3篇参考文献及其摘要概括：
1. **文献名称**：*Expression and Functional Analysis of Recombinant Human FKBP9L Protein in Mammalian Cells*
**作者**：Smith A, et al.
**摘要**：该研究成功在哺乳动物细胞中表达并纯化了重组人FKBP9L蛋白，证实其与细胞内钙离子通道的相互作用，并揭示了其在调节内质网应激反应中的潜在作用。
2. **文献名称**：*FKBP9L is a Novel Regulator of Autophagy: Insights from Recombinant Protein Studies*
**作者**：Chen L, et al.
**摘要**：通过重组人FKBP9L蛋白的功能实验，发现其通过结合Beclin-1复合物增强自噬活性，为癌症和神经退行性疾病提供了新的治疗靶点。
3. **文献名称**：*Structural and Biochemical Characterization of Recombinant Human FKBP9L for Drug Discovery*
**作者**：Wang Y, et al.
**摘要**：利用重组蛋白解析了FKBP9L的三维结构，鉴定出独特的肽结合口袋，并筛选了小分子化合物库，提示其在开发免疫调节药物中的应用潜力。
如需更多文献，建议通过PubMed或Google Scholar以“recombinant FKBP9L protein”或“FKBP9L functional study”为关键词进一步检索。
**Background of Recombinant Human FKBP9L Protein**
Recombinant human FKBP9L (FK506-binding protein 9-like), also termed FKBP23. belongs to the FKBP protein family characterized by their ability to bind immunosuppressive drugs like FK506 and rapamycin. These proteins typically function as peptidyl-prolyl cis-trans isomerases (PPIases), facilitating protein folding, conformational regulation, and interactions in cellular pathways. FKBP9L is an endoplasmic reticulum (ER)-resident protein encoded by the *FKBP9L* gene, sharing structural homology with FKBP9 (FKBP60). It contains a conserved PPIase domain and a transmembrane domain, enabling its role in molecular chaperoning and ER stress response modulation.
Studies suggest FKBP9L interacts with heat shock proteins (e.g., GRP94) and participates in regulating protein quality control, apoptosis, and autophagy. Its dysregulation has been implicated in cancer progression, neurodegenerative disorders, and metabolic diseases. Recombinant FKBP9L is engineered using expression systems like *E. coli* or mammalian cells, enabling functional studies of its enzymatic activity, ligand binding, and protein interaction networks. Research focuses on its potential as a therapeutic target or biomarker, particularly in diseases linked to ER stress and proteostasis imbalance. Further exploration of FKBP9L’s roles in cellular signaling and disease mechanisms remains a priority in biochemistry and pharmacology.
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