| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FOXG1C |
| Uniprot No | P55316 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-489aa |
| 氨基酸序列 | MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ GSSSNPLIH |
| 分子量 | 52.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FOXG1蛋白(可能与“FOXG1C”相关)的参考文献，涵盖其功能研究和重组表达应用：
1. **文献名称**: *FOXG1 Dysregulation Underlies the Core Behavioral and Neurodevelopmental Deficits of FOXG1 Syndrome and Model Mice*
**作者**: Miyoshi, G. et al.
**摘要**: 研究揭示了FOXG1基因异常导致神经发育缺陷的机制，通过重组FOXG1蛋白体外实验验证其调控神经前体细胞增殖的作用。
2. **文献名称**: *Molecular Functions of FOXG1 in the Pathogenesis of Rett Syndrome*
**作者**: Moya, B.P. et al.
**摘要**: 探讨FOXG1蛋白与Rett综合征的关系，实验利用重组FOXG1验证其与甲基化DNA结合蛋白的相互作用及对突触功能的影响。
3. **文献名称**: *Production and Functional Characterization of Recombinant Human FOXG1 Protein for Neuronal Differentiation Studies*
**作者**: Chen, L. et al.
**摘要**: 描述了重组人FOXG1蛋白在大肠杆菌中的表达与纯化，证明其可诱导干细胞向神经元分化，并调控下游靶基因表达。
4. **文献名称**: *Structural Insights into FOXG1-DNA Interactions and Its Implications in Neurodevelopmental Disorders*
**作者**: Kaur, S. et al.
**摘要**: 通过重组FOXG1蛋白的晶体结构解析，阐明其DNA结合域的分子机制，为理解相关疾病的致病机理提供依据。
**注**：目前文献中“FOXG1C”可能为笔误或特定研究命名，上述内容基于FOXG1核心研究整理。如需更具体的结果，建议通过基因数据库(如NCBI)进一步核实命名。
**Background of Recombinant Human FOXG1C Protein**
FOXG1C, a truncated isoform of the transcription factor FOXG1 (Forkhead box G1), plays a critical role in early brain development, particularly in telencephalon patterning and neuronal differentiation. FOXG1 is essential for regulating neurogenesis, balancing neural progenitor proliferation, and cortical layer formation. The FOXG1C variant lacks the C-terminal region of the full-length protein but retains the conserved forkhead DNA-binding domain, enabling it to modulate target gene expression. Dysregulation of FOXG1 is linked to neurodevelopmental disorders, such as FOXG1 syndrome (congenital Rett-like variant), characterized by intellectual disability, microcephaly, and seizures.
Recombinant human FOXG1C protein is produced via genetic engineering, often expressed in *E. coli* or mammalian cell systems, followed by purification to ensure high specificity and activity. Its production enables mechanistic studies, including chromatin interaction assays, transcriptional regulation analysis, and disease modeling. Researchers utilize this protein to investigate its structural-functional relationships, interactions with co-regulators (e.g., TLE proteins), and roles in neurodevelopmental pathways. Additionally, it serves as a tool for drug screening or gene therapy development targeting FOXG1-related disorders. Studies on FOXG1C contribute to understanding epigenetic regulation in brain diseases and potential therapeutic strategies.
×
