| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FOXP4 |
| Uniprot No | Q8IVH2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-680aa |
| 氨基酸序列 | MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP GPPLGAPNPS ASGPPEDRDL EEELPGEELS |
| 分子量 | 73.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FOXP4蛋白的参考文献示例(文献信息为模拟示例，仅供参考)：
1. **《FOXP4的结构与DNA结合功能分析》**
*作者：Zhang et al. (2018)*
摘要：本研究通过重组表达纯化人FOXP4蛋白，解析其晶体结构，发现其Forkhead结构域特异性结合DNA靶序列，揭示了FOXP4在转录调控中的分子机制。
2. **《重组FOXP4在肺癌细胞增殖中的作用》**
*作者：Li & Wang (2020)*
摘要：利用重组FOXP4蛋白处理肺癌细胞，证明其通过抑制EGFR信号通路调控细胞增殖和迁移，提示FOXP4可能作为肿瘤抑制因子发挥作用。
3. **《重组FOXP4与FOXP家族蛋白的功能互作》**
*作者：Chen et al. (2019)*
摘要：通过体外实验发现重组人FOXP4与FOXP1/2形成异源二聚体，协同调控靶基因表达，为神经发育和免疫调节提供了新机制依据。
4. **《重组FOXP4的高效表达与纯化策略优化》**
*作者：Kimura et al. (2021)*
摘要：开发了一种基于大肠杆菌的重组FOXP4蛋白高效表达和纯化方法，优化了溶解条件，为后续功能研究提供高活性蛋白制剂。
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**注**：以上为模拟文献，实际引用需查询具体数据库(如PubMed、Web of Science)获取真实发表的研究。
Recombinant human FOXP4 protein is a genetically engineered version of the forkhead box protein P4 (FOXP4), a member of the FOX family of transcription factors involved in regulating gene expression. FOXP4 contains a conserved forkhead DNA-binding domain and plays critical roles in organ development, immune regulation, and cell differentiation, particularly in the lung, nervous system, and cardiovascular tissues. It shares functional overlap with other FOXP family members, such as FOXP2 (linked to speech disorders) and FOXP3 (a key regulator of immune tolerance). FOXP4 is implicated in embryonic development and tissue homeostasis, with dysregulation observed in cancers (e.g., lung, gastric) and neurodevelopmental disorders. Recombinant FOXP4 is typically produced in bacterial, yeast, or mammalian expression systems, enabling studies of its molecular interactions, signaling pathways, and potential therapeutic applications. Current research focuses on its role in tumor progression, synaptic plasticity, and epithelial-mesenchymal transition, leveraging recombinant protein tools to explore FOXP4 as a biomarker or therapeutic target. These studies aim to clarify its dual context-dependent roles in both promoting and suppressing diseases, highlighting its complexity in cellular regulation.
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