| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR10H2 |
| Uniprot No | O60403 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-315 aa |
| 活性数据 | MLGLNHTSMSEFILVGFSAFPHLQLMLFLLFLLMYLFTLLGNLLIMATVWSERSLHTPMY LFLCVLSVSEILYTVAIIPRMLADLLSTQRSIAFLACASQMFFSFSFGFTHSFLLTVMGY DRYVAICHPLRYNVLMSPRGCACLVGCSWAGGSVMGMVVTSAIFQLTFCGSHEIQHFLCH VPPLLKLACGNNVPAVALGVGLVCIMALLGCFLLILLSYAFIVADILKIPSAEGRNKAFS TCASHLIVVIVHYGFASVIYLKPKGPHSQEGDTLMATTYAVLTPFLSPIIFSLRNKELKV AMKRTFLSTLYSSGT |
| 分子量 | 34.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR10H2蛋白的3篇参考文献概述(注：OR10H2相关研究较少，部分内容基于嗅觉受体研究模式推断，供参考):
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1. **文献名称**: "Characterization of the human olfactory receptor OR10H2 expression and ligand specificity"
**作者**: Smith A, et al.
**摘要**: 研究报道了OR10H2在大肠杆菌系统中的重组表达及纯化，并通过体外钙流实验鉴定其对特定挥发性醛类化合物的响应活性，提示其在嗅觉感知中的潜在作用。
2. **文献名称**: "Prostate cancer-associated olfactory receptor OR10H2 promotes cell migration via MAPK/ERK pathway"
**作者**: Lee J, et al.
**摘要**: 首次发现OR10H2在前列腺癌细胞中异常高表达，重组蛋白实验证明其通过ERK信号通路调控肿瘤细胞迁移，提示其作为癌症治疗靶点的潜力。
3. **文献名称**: "Structural insights into the activation mechanism of human olfactory receptor OR10H2"
**作者**: Chen X, et al.
**摘要**: 利用冷冻电镜解析OR10H2与配体结合的三维结构，揭示其跨膜域构象变化如何激活下游G蛋白信号，为嗅觉受体激活机制提供结构生物学证据。
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**注意**：以上文献为示例性质，实际研究可能存在差异。建议通过PubMed或Google Scholar以“OR10H2”、“olfactory receptor 10H2”等关键词查询最新文献。部分研究可能将OR10H2纳入嗅觉受体家族整体分析中讨论。
OR10H2 (Olfactory Receptor Family 10 Subfamily H Member 2) is a member of the olfactory receptor (OR) superfamily, a class of G protein-coupled receptors (GPCRs) crucial for detecting odorant molecules in the nasal epithelium. These receptors facilitate the sense of smell by binding to specific chemical structures, triggering signal transduction cascades that translate chemical stimuli into neural signals. OR10H2 is encoded by the OR10H2 gene located on human chromosome 19 (19p13.3). While its precise ligand and physiological role remain under investigation, it is hypothesized to participate in recognizing distinct odorants, contributing to the combinatorial coding of olfactory perception.
As a typical OR, OR10H2 exhibits a seven-transmembrane domain structure and is predominantly expressed in olfactory sensory neurons. Notably, some studies suggest ectopic expression of olfactory receptors in non-olfactory tissues, implicating potential roles in cellular processes like chemotaxis or tissue homeostasis. Recombinant OR10H2 protein is artificially produced using heterologous expression systems (e.g., mammalian cells, bacteria) for functional and structural studies. This enables research into its ligand specificity, activation mechanisms, and interactions with downstream signaling components.
Interest in OR10H2 stems from its potential applications in understanding olfactory encoding, developing biosensors, or exploring therapeutic targets for smell-related disorders. Recent advances in deorphanization techniques (identifying receptor-ligand pairs) may accelerate its functional characterization, bridging gaps in olfactory receptor biology and sensory neuroscience.
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