关键信息
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基因名
IL-6
- 应用
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别名
IL-6；Interleukin-6 receptor subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05231
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表达区间
28-212aa
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氨基酸序列
APVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNM CESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLE YLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLT KLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-6 (IL-6) is a multifunctional cytokine involved in various physiological and pathological processes, including immune response, inflammation, and hematopoiesis. It plays a crucial role in the body’s defense mechanisms, particularly during infections and injuries. However, dysregulation of IL-6 production is linked to a variety of diseases, such as autoimmune disorders, chronic inflammatory conditions, and cancers. Due to its central role in inflammation and immune response, IL-6 has emerged as a significant target for therapeutic intervention. Recombinant IL-6 protein has been studied for its potential applications in both basic research and clinical settings, offering insights into cytokine signaling pathways and the development of targeted therapies. Researchers are particularly interested in its role in promoting T cell differentiation, modulating immune responses, and its potential utility in cell-based therapies. Furthermore, understanding the structure-function relationship of IL-6 can facilitate the design of more effective inhibitors or agonists for therapeutic purposes. As such, the study of recombinant IL-6 protein not only contributes to fundamental biological knowledge but also paves the way for innovative treatments for diseases characterized by altered IL-6 signaling.
