| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR10S1 |
| Uniprot No | Q8NGN2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-331 aa |
| 活性数据 | MTSRSVCEKMTMTTENPNQTVVSHFFLEGLRYTAKHSSLFFLLFLLIYSITVAGNLLILL TVGSDSHLSLPMYHFLGHLSFLDACLSTVTVPKVMAGLLTLDGKVISFEGCAVQLYCFHF LASTECFLYTVMAYDRYLAICQPLHYPVAMNRRMCAEMAGITWAIGATHAAIHTSLTFRL LYCGPCHIAYFFCDIPPVLKLACTDTTINELVMLASIGIVAAGCLILIVISYIFIVAAVL RIRTAQGRQRAFSPCTAQLTGVLLYYVPPVCIYLQPRSSEAGAGAPAVFYTIVTPMLNPF IYTLRNKEVKHALQRLLCSSFRESTAGSPPP |
| 分子量 | 36.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR10S1蛋白的模拟参考文献示例(仅供信息参考，非真实文献)：
1. **文献名称**: *"Heterologous Expression and Functional Characterization of Human Olfactory Receptor OR10S1 in HEK293 Cells"*
**作者**: Zhang L, et al.
**摘要**: 本研究在HEK293细胞中成功表达了重组OR10S1蛋白，并通过钙离子荧光信号检测证实其能被特定气味分子(如香草醛)激活，揭示了OR10S1在嗅觉感知中的潜在作用。
2. **文献名称**: *"Structural Analysis of OR10S1: A Computational and Cryo-EM Study"*
**作者**: Kim S, et al.
**摘要**: 通过冷冻电镜技术和分子对接模拟解析了重组OR10S1的三维结构，发现其配体结合口袋具有独特的疏水特性，为设计靶向该受体的化合物提供了依据。
3. **文献名称**: *"OR10S1 Expression in Non-Olfactory Tissues: Implications for Cancer Biomarker Discovery"*
**作者**: Wang X, et al.
**摘要**: 利用重组OR10S1蛋白制备抗体，发现其在结直肠癌组织中异常高表达，并通过体外实验表明其可能通过调控MAPK通路促进肿瘤细胞迁移。
4. **文献名称**: *"High-Yield Purification of Recombinant OR10S1 Using a Novel Detergent Screening Strategy"*
**作者**: Gupta R, et al.
**摘要**: 开发了一种基于去垢剂筛选的优化方案，显著提高了重组OR10S1的溶解性和稳定性，为后续生化研究提供了高纯度蛋白样品。
**备注**：以上文献为模拟生成，实际研究中建议通过PubMed、Google Scholar等数据库检索真实文献(关键词：OR10S1. recombinant protein, olfactory receptor)。该受体相关真实研究可能较少，部分功能仍有待探索。
**OR10S1** is a human olfactory receptor protein belonging to the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) crucial for detecting odorants and mediating the sense of smell. Encoded by the *OR10S1* gene, it is classified under subfamily 10S within the OR superfamily. Olfactory receptors like OR10S1 are primarily expressed in olfactory sensory neurons of the nasal epithelium, where they bind specific odorant molecules to initiate signal transduction.
As a **class A GPCR**, OR10S1 features seven transmembrane helices and interacts with odorants through a ligand-binding pocket formed by these helices. However, the exact odorant ligands and downstream signaling mechanisms for OR10S1 remain poorly characterized compared to other ORs. Recombinant OR10S1 protein is typically produced in heterologous systems (e.g., HEK293 or insect cells) for structural and functional studies. Its expression and purification enable research into its ligand specificity, activation pathways, and potential roles beyond olfaction, such as in non-chemosensory tissues, though such roles are not well-defined.
Despite advances in OR research, OR10S1 remains understudied, with limited data on its physiological or pathological relevance. Studying recombinant OR10S1 may clarify its contributions to sensory perception, disease biomarkers, or therapeutic targets, but further research is needed to elucidate its biological significance.
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