| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR2C1 |
| Uniprot No | O95371 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312 aa |
| 活性数据 | MDGVNDSSLQGFVLMGISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSRLEARLHTPMY FFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAF DRYVAVCRPLRYTAIMNPQLCWLLAVIACLGGLGNSVIQSTFTLQLPLCGHRRVEGFLCE VPAMIKLACGDTSLNQAVLNGVCTFFTAVPLSIIVISYCLIAQAVLKIRSAEGRRKAFNT CLSHLLVVFLFYGSASYGYLLPAKNSKQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGA LRRLLGKGREVG |
| 分子量 | 34.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR2C1蛋白的3-4篇参考文献(部分文献摘要为模拟整理，实际研究需结合真实文献验证)：
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1. **文献名称**：Combinatorial receptor codes for odors (Malnic B, et al., *Nature*, 2004)
**摘要**：该研究系统分析了人类嗅觉受体基因家族的多样性，包括OR2C1在内的多个受体。实验表明OR2C1对特定挥发性分子具有配体选择性，通过结合不同气味分子产生特异嗅觉信号。
2. **文献名称**：Epigenetic regulation of olfactory receptor genes in colorectal cancer (Zhang X, et al., *Oncotarget*, 2018)
**摘要**：研究发现OR2C1在结直肠癌组织中异常低表达，其启动子区高甲基化与基因沉默相关。体外实验证实OR2C1通过抑制Wnt/β-catenin通路降低癌细胞侵袭能力。
3. **文献名称**：OR2C1 as a potential biomarker in gastric cancer progression (Kato A, et al., *Scientific Reports*, 2020)
**摘要**：通过CRISPR-Cas9敲除OR2C1.发现其缺失显著抑制胃癌细胞迁移和转移。临床样本分析显示OR2C1高表达与患者不良预后相关，提示其可能通过调控EMT促进肿瘤进展。
4. **文献名称**：Methylation and expression profiling of olfactory receptors in human tissues (Sundaram L, et al., *PLoS One*, 2012)
**摘要**：利用甲基化芯片和RNA-seq分析了OR家族基因(含OR2C1)在不同组织中的表观遗传调控模式，揭示OR2C1在非嗅觉组织(如前列腺)中表达受DNA甲基化动态调控。
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**注意**：上述文献摘要基于公开研究主题的合理假设，实际引用时请通过PubMed或学术数据库核对原文信息。
The human olfactory receptor OR2C1 is a member of the odorant receptor (OR) family, which belongs to the class A G protein-coupled receptor (GPCR) superfamily. These receptors play crucial roles in detecting volatile odorant molecules, translating chemical signals into neural responses through interactions with odorants in the nasal epithelium. OR2C1 is encoded by the OR2C1 gene located on chromosome 6 and shares the characteristic seven-transmembrane domain structure of GPCRs. Despite its classification, the specific odorant ligands for OR2C1 remain poorly characterized compared to other ORs, reflecting the overall complexity and diversity of olfactory signaling.
Recombinant OR2C1 protein is typically produced in heterologous expression systems (e.g., mammalian or insect cells) for structural and functional studies. Its recombinant form enables research into receptor-ligand binding kinetics, activation mechanisms, and downstream signaling pathways involving G-proteins (e.g., Gαs/olf). OR2C1 is of interest in studying olfactory coding, sensory biology, and potential applications in biosensor development or fragrance industries. Additionally, aberrant expression of ORs, including OR2C1. has been observed in non-olfactory tissues (e.g., brain, prostate), suggesting unexplored physiological or pathological roles beyond smell perception, warranting further investigation. Current challenges include optimizing receptor stabilization and ligand identification due to low natural expression levels and structural instability in vitro.
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