| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR2T8 |
| Uniprot No | A6NH00 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312 aa |
| 活性数据 | MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFL LSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFLPTLGGGECFLLAAMAYDR YAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFCETP VLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCS SHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALT RCMGRCVALSRE |
| 分子量 | 34.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人OR2T8蛋白的研究目前较为有限，以下是模拟的参考文献格式(具体文献可能需要通过专业数据库验证)：
1. **文献名称**: "Functional Characterization of Recombinant Olfactory Receptor OR2T8 in Heterologous Expression Systems"
**作者**: Smith A., et al.
**摘要**: 本研究在HEK293细胞中重组表达了OR2T8蛋白，利用cAMP报告系统鉴定其潜在配体，发现其可被特定醛类化合物激活，提示其在嗅觉感知中的功能。
2. **文献名称**: "OR2T8 Expression in Non-Olfactory Tissues and Its Recombinant Production for Cancer Studies"
**作者**: Zhang L., et al.
**摘要**: 报道OR2T8在肺肿瘤细胞中的异常表达，通过重组蛋白研究其与细胞迁移的关联，发现抑制OR2T8可降低癌细胞侵袭性。
3. **文献名称**: "Structural Insights into OR2T8 Through Recombinant Protein Expression and Molecular Modeling"
**作者**: Kim J., et al.
**摘要**: 通过重组OR2T8蛋白的体外折叠优化及分子对接技术，预测其配体结合口袋结构，为嗅觉受体靶向药物开发提供依据。
4. **文献名称**: "High-Yield Production of Recombinant Human OR2T8 in Insect Cells for Antibody Development"
**作者**: Müller R., et al.
**摘要**: 采用杆状病毒-昆虫细胞系统高效表达OR2T8.纯化后用于制备特异性抗体，验证其在嗅觉上皮组织中的定位。
**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar或Web of Science检索确认。建议使用关键词“OR2T8 recombinant”“olfactory receptor OR2T8”进一步查询。
OR2T8. a member of the olfactory receptor (OR) family, is a G protein-coupled receptor (GPCR) primarily associated with odorant detection. ORs are encoded by the largest gene family in vertebrates, playing crucial roles in recognizing volatile chemical cues. Located on human chromosome 1. the OR2T8 gene spans a single exon and is expressed in olfactory sensory neurons, where it likely binds specific odorant molecules. Though its precise endogenous ligands remain under investigation, OR2T8 is implicated in detecting sulfur-containing compounds or phosphonates, potentially contributing to odor discrimination.
Interestingly, OR receptors like OR2T8 exhibit “ectopic” expression in non-olfactory tissues such as testes, gut, and lungs, suggesting non-canonical functions in processes like cell migration or hormone regulation. Genetic variations in OR2T8 may influence individual odor perception differences.
Recent studies explore OR2T8's applications in biosensor development and disease biomarker identification due to its selective ligand-binding properties. Challenges persist in deorphaning ORs like OR2T8. as conventional GPCR assays often fail to reflect their native activation mechanisms. Nonetheless, OR2T8 serves as a model for studying the evolution of chemosensory systems and receptor-ligand specificity. Its characterization could advance synthetic biology tools and therapeutic targeting of extra-nasal OR signaling pathways.
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