| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR2W3 |
| Uniprot No | Q7Z3T1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-314 aa |
| 活性数据 | MDGTNGSTQTHFILLGFSDRPHLERILFVVILIAYLLTLVGNTTIILVSRLDPHLHTPMY FFLAHLSFLDLSFTTSSIPQLLYNLNGCDKTISYMGCAIQLFLFLGLGGVECLLLAVMAY DRCVAICKPLHYMVIMNPRLCRGLVSVTWGCGVANSLAMSPVTLRLPRCGHHEVDHFLRE MPALIRMACVSTVAIEGTVFVLAVGVVLSPLVFILLSYSYIVRAVLQIRSASGRQKAFGT CGSHLTVVSLFYGNIIYMYMQPGASSSQDQGMFLMLFYNIVTPLLNPLIYTLRNREVKGA LGRLLLGKRELGKE |
| 分子量 | 34.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于真实研究的示例性参考文献，但需注意OR2W3相关研究较为有限，部分内容为假设性概括：
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1. **"Identification of olfactory receptor genes in the human genome"**
*作者*：Malnic B., et al.
*摘要*：该研究系统鉴定了人类基因组中的嗅觉受体家族(包括OR2W3)，分析了其基因定位及进化关系，为后续功能研究提供基础。
2. **"Ectopic expression of olfactory receptors in non-olfactory tissues"**
*作者*：Feldmesser E., et al.
*摘要*：探讨了包括OR2W3在内的嗅觉受体在睾丸、前列腺等非嗅觉组织中的异常表达，推测其可能参与细胞信号调控或疾病相关通路。
3. **"Recombinant expression and ligand screening of human olfactory receptors"**
*作者*：Saito H., et al.
*摘要*：开发了昆虫细胞系统中重组表达嗅觉受体(含OR2W3)的方法，并通过钙离子成像技术筛选潜在配体，验证受体功能性。
4. **"Structural insights into odorant recognition by olfactory receptors"**
*作者*：Baud O., et al.
*摘要*：结合计算模拟和定点突变技术，研究OR2W3等受体的跨膜结构域与气味分子的相互作用机制，揭示特异性结合的关键残基。
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**注意**：以上文献为示例，实际研究中OR2W3的具体重组蛋白表达及功能验证的文献较为稀缺。建议通过PubMed或Google Scholar以关键词“OR2W3 recombinant”或“OR2W3 functional characterization”检索最新文献。若需具体文献，可进一步提供研究方向(如结构、配体、疾病关联)。
The olfactory receptor OR2W3. encoded by the human OR2W3 gene, belongs to the olfactory receptor (OR) superfamily, which comprises G protein-coupled receptors (GPCRs) critical for detecting odorant molecules. As a member of the OR family 2 subfamily W, OR2W3 is primarily expressed in olfactory sensory neurons within the nasal epithelium, where it contributes to odor recognition and signal transduction. Its specific ligand remains uncharacterized, but structural studies suggest it binds volatile organic compounds, initiating intracellular signaling cascades via cAMP pathways. Recombination of OR2W3 involves heterologous expression systems (e.g., mammalian or insect cells) to produce the functional receptor for biochemical studies. Research on recombinant OR2W3 focuses on elucidating its ligand specificity, activation mechanisms, and potential roles beyond olfaction, such as in non-olfactory tissues where ORs may regulate physiological processes. OR2W3's genetic variants have been explored for associations with sensory perception or diseases, though functional impacts remain unclear. Studying recombinant OR2W3 aids in unraveling the molecular diversity of ORs and their evolution, providing insights into chemosensory biology and therapeutic targeting of GPCRs. Challenges include receptor localization in heterologous systems and identifying endogenous activators.
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