| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR6C75 |
| Uniprot No | A6NL08 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312 aa |
| 活性数据 | MRNSTAVTDFILLGLTSDPQWQVVLFIFLLVTYMLSVTGNLIIITLTLSDPHLQTPMYFF LRNFSFLEISFTSVCIPRFLVTVVTGNRTISYNGCVAQLFFFIFLGVTEFYLLAAMSYDR CMAICKPLHYTIIMSTRVCTLLVFSSWLAGFLIIFPPVMLLLQLDFCASNVIDHFICDSS PMLQLSCTNTHFLELMAFFLAVVTLMVTLTLVILSYTNIIRTILKIPSMSQRKKAFSTCS SHMIVVSISYSSCIFMYIKTSARERVTLSKGVAVLNTSVAPLLNPFIYTLRNKQVKQAFK SMVQKMIFSLNK |
| 分子量 | 35.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR6C75蛋白的假设性参考文献示例（基于学术文献常见研究方向虚构，实际文献需通过数据库检索确认）：
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1. **标题**：**"Heterologous Expression and Structural Characterization of Human Olfactory Receptor OR6C75 in HEK293 Cells"**
**作者**：Smith JL, et al.
**摘要**：本研究通过哺乳动物表达系统（HEK293）成功实现了OR6C75蛋白的重组表达，并利用冷冻电镜解析了其跨膜结构域的三维构象，揭示了其可能的配体结合口袋特征。
2. **标题**：**"OR6C75 as a Potential Biomarker for Nasopharyngeal Carcinoma: Ligand Screening and Functional Analysis"**
**作者**：Chen X, et al.
**摘要**：通过高通量配体筛选发现OR6C75对特定挥发性硫化物（如二甲基二硫）具有高亲和力，并发现其在鼻咽癌患者组织中表达异常上调，提示其可能作为疾病生物标志物。
3. **标题**：**"Genetic Variation in OR6C75 Alters Odorant Perception: A Population-Based GWAS Study"**
**作者**：Gupta R, et al.
**摘要**：通过全基因组关联分析（GWAS）发现OR6C75基因的单核苷酸多态性（SNP rs782032）与人类对蘑菇类气味的感知敏感性显著相关，验证了该受体在嗅觉信号通路中的功能。
4. **标题**：**"Optimization of OR6C75 Protein Purification Using a Novel Baculovirus-Insect Cell System"**
**作者**：Tanaka H, et al.
**摘要**：开发了一种基于杆状病毒-昆虫细胞的重组OR6C75蛋白高效纯化方案，结合表面活性剂筛选提高了蛋白稳定性，为后续功能研究提供了高纯度样品。
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**注**：以上文献为模拟虚构内容，实际研究中建议通过PubMed、Google Scholar等平台以“OR6C75”、“olfactory receptor 6C75”等关键词检索真实文献。
**Background of Recombinant Human OR6C75 Protein**
The olfactory receptor OR6C75 belongs to the G protein-coupled receptor (GPCR) superfamily, specifically categorized under olfactory receptors (ORs), which play critical roles in detecting odorants and mediating chemosensory signaling. Human OR6C75 is encoded by the OR6C75 gene located on chromosome 12. While most olfactory receptors are predominantly expressed in olfactory sensory neurons, emerging studies suggest ectopic expression in non-olfactory tissues, including the brain, testes, and kidneys, hinting at potential roles beyond smell, such as cellular communication or metabolic regulation.
Recombinant OR6C75 protein is engineered via heterologous expression systems (e.g., mammalian, insect, or bacterial cells) to study its structure, ligand specificity, and downstream signaling. Its production enables functional characterization, such as identifying activating ligands or elucidating interaction networks. Research on OR6C75 remains limited compared to other ORs, but its exploration may uncover novel mechanisms in sensory biology or therapeutic targets for diseases linked to olfactory dysfunction or ectopic receptor activity. Challenges include low natural abundance, difficulty in ligand identification, and receptor stability in vitro. Advances in protein engineering and CRISPR-based models could accelerate its functional decoding in physiological and pathological contexts.
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