| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR8D2 |
| Uniprot No | Q9GZM6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-311 aa |
| 活性数据 | MATSNHSSGAEFILAGLTQRPELQLPLFLLFLGIYVVTVVGNLGMIFLIALSSQLYPPVY YFLSHLSFIDLCYSSVITPKMLVNFVPEENIISFLECITQLYFFLIFVIAEGYLLTAMEY DRYVAICRPLLYNIVMSHRVCSIMMAVVYSLGFLWATVHTTRMSVLSFCRSHTVSHYFCD ILPLLTLSCSSTHINEILLFIIGGVNTLATTLAVLISYAFIFSSILGIHSTEGQSKAFGT CSSHLLAVGIFFGSITFMYFKPPSSTTMEKEKVSSVFYITIIPMLNPLIYSLRNKDVKNA LKKMTRGRQSS |
| 分子量 | 34.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于现有研究背景推测的可能相关文献示例（注：OR8D2研究较为有限，实际文献需通过学术数据库验证）：
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1. **"Functional characterization of human olfactory receptor OR8D2 as a steroid sensor"**
*Authors: Smith J, et al. (2020)*
**摘要**：通过重组表达OR8D2于HEK293细胞，发现其对类固醇类分子（如雄烯酮）具有特异性响应，激活下游cAMP信号通路，提示其可能参与人体信息素感知。
2. **"Heterologous expression and ligand screening of human olfactory receptors"**
*Authors: Zhang L, et al. (2018)*
**摘要**：建立高通量嗅觉受体重组表达系统，包含OR8D2在内的50种受体被成功表达，通过钙流检测筛选潜在配体，发现OR8D2对特定醛类化合物有微弱反应。
3. **"Genomic organization and polymorphisms of the human OR8D2 olfactory receptor gene"**
*Authors: García-Sánchez A, et al. (2015)*
**摘要**：解析OR8D2基因结构及人群遗传变异，发现其启动子区域多态性与嗅觉功能障碍存在关联，但未直接验证重组蛋白功能。
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**注意**：上述文献为模拟示例，实际研究中OR8D2的功能性数据较少，建议通过 **PubMed/Google Scholar** 检索最新文献（关键词：OR8D2, recombinant expression, olfactory receptor），或关注嗅觉受体共性技术论文（如重组表达方法学）间接参考。
Recombinant human OR8D2 protein is a chemically synthesized or heterologously expressed form of the olfactory receptor OR8D2, a class A G protein-coupled receptor (GPCR) encoded by the OR8D2 gene. As part of the olfactory receptor family, OR8D2 is primarily associated with the detection of odorant molecules in the olfactory epithelium, contributing to the sense of smell. Olfactory receptors like OR8D2 are characterized by seven transmembrane domains and signal through G protein-mediated pathways, typically involving cAMP or inositol phosphate signaling cascades. While the specific ligands for OR8D2 remain under investigation, its structural and functional studies are of interest for understanding odorant recognition mechanisms. Recombinant OR8D2 is commonly produced in heterologous systems (e.g., mammalian or insect cells) for biochemical characterization, ligand screening, and structural studies. Its expression and purification enable research into receptor-ligand interactions, receptor activation dynamics, and potential applications in biosensor development or fragrance-related industries. Challenges in working with OR8D2 include low natural expression levels, complex membrane protein folding requirements, and the need for specialized assays to detect odorant-induced signaling. Current research aims to map its odorant specificity, elucidate its role in human olfaction, and explore possible non-olfactory functions in tissues where it might be ectopically expressed.
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