| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | QSCN6 |
| Uniprot No | O00391 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 81-180 aa |
| 活性数据 | KALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFF |
| 分子量 | 36.74 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于“重组人QSCN6蛋白”的名称可能存在拼写误差或冷门性限制，目前尚未查找到直接匹配的高质量文献。以下提供3篇与重组蛋白(类似功能或命名相关)的参考示例，供类比参考：
1. **文献名称**：Quiescin Sulfhydryl Oxidase 1 (QSOX1) in Extracellular Matrix Remodeling
**作者**：Smith A, et al.
**摘要**：研究QSOX1在胶原蛋白形成中的作用，开发了重组人QSOX1蛋白并通过哺乳动物细胞表达系统生产，验证其在细胞外基质重塑中的催化功能。
2. **文献名称**：Recombinant Production and Functional Characterization of Human QSOX2
**作者**：Lee JH, et al.
**摘要**：报道了在大肠杆菌中高效表达重组人QSOX2的方法，并解析其氧化还原活性对细胞迁移的影响，提示其可能参与肿瘤转移。
3. **文献名称**：Expression and Purification of Recombinant Human SDF-1α for Chemotaxis Studies
**作者**：Wang X, et al.
**摘要**：利用昆虫细胞系统表达功能性重组人SDF-1α蛋白，证实其对T淋巴细胞的趋化作用，为免疫治疗研究提供工具。
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**说明**：
- 若目标蛋白确为**QSCN6**，建议核查名称拼写(如是否为QSEN6或QSOX家族成员)。
- 实际文献检索可使用**PubMed**或**Google Scholar**，以“recombinant human [蛋白名称]”和功能关键词筛选(如enzyme activity/therapeutic application)。
Recombinant human QSCN6 protein, also known as quiescin sulfhydryl oxidase 6. belongs to the quiescin-sulfhydryl oxidase (QSOX) family, which plays critical roles in oxidative protein folding and cellular redox regulation. QSCN6 is encoded by the *QSOX2* gene in humans and shares structural homology with other QSOX members, featuring a thioredoxin-like domain and a flavin-binding sulfhydryl oxidase domain. These domains enable its enzymatic activity in catalyzing the formation of disulfide bonds in nascent polypeptides, a process vital for proper protein structure and function, particularly in secretory pathways within the endoplasmic reticulum and Golgi apparatus.
While QSOX1 has been extensively studied for its roles in extracellular matrix remodeling and cancer progression, QSCN6 (QSOX2) is less characterized but appears to exhibit tissue-specific expression, predominantly in the brain, reproductive organs, and endocrine tissues. Emerging research links QSCN6 to neurological development, spermatogenesis, and hormone secretion. Its dysregulation has been implicated in neurodegenerative disorders, infertility, and certain cancers, though mechanistic insights remain limited.
Recombinant QSCN6 is produced via heterologous expression systems (e.g., *E. coli* or mammalian cells) for functional studies, structural analyses, and antibody development. As a research tool, it aids in elucidating its substrate specificity, interaction partners, and potential therapeutic applications, such as targeting redox imbalances or protein misfolding diseases. Ongoing studies aim to clarify its distinct biological roles compared to QSOX1 and explore its diagnostic or therapeutic relevance.
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