| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RALYL |
| Uniprot No | Q86SE5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-291 aa |
| 活性数据 | MTGKTQTSNV TNKNDPKSIN SRVFIGNLNT AIVKKVDIEA IFSKYGKIVG CSVHKGYAFV QYMSERHARA AVAGENARVI AGQPLDINMA GEPKPYRPKP GNKRPLSALY RLESKEPFLS VGGYVFDYDY YRDDFYNRLF DYHGRVPPPP RAVIPLKRPR VAVTTTRRGK GVFSMKGGSR STASGSTGSK LKSDELQTIK KELTQIKTKI DSLLGRLEKI EKQQKAEAEA QKKQLEESLV LIQEECVSEI ADHSTEEPAE GGPDADGEEM TDGIEEDFDE DGGHELFLQI K |
| 分子量 | 32.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RALYL蛋白的3篇示例参考文献(注：部分文献为示例性虚构，实际引用请核实真实来源)：
1. **文献名称**: "RALYL Promotes Glioblastoma Progression via Transcriptional Activation of oncogenic signaling pathways"
**作者**: Zhang Y. et al.
**摘要**: 研究发现RALYL在胶质母细胞瘤中异常高表达，通过激活Wnt/β-catenin信号通路促进肿瘤细胞增殖和侵袭，提示其作为潜在治疗靶点。
2. **文献名称**: "Structural Insights into RALYL-DNA Interaction by Cryo-EM Analysis"
**作者**: Smith J. et al.
**摘要**: 该研究通过冷冻电镜技术解析了RALYL蛋白与DNA结合的复合物结构，揭示了其C端结构域在调控靶基因转录中的关键作用。
3. **文献名称**: "RALYL Regulates Cortical Neurogenesis during Mouse Embryonic Development"
**作者**: Li X. et al.
**摘要**: 利用条件性基因敲除小鼠模型，证明RALYL通过调控Sox2等神经干细胞标志物的表达，影响大脑皮层神经发生及神经回路形成。
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**注意事项**：
- 上述文献及摘要为示例性质，实际研究中建议通过PubMed/Google Scholar等平台以“RALYL protein”或“RALYL gene”为关键词检索最新研究。
- RALYL相关研究尚处于早期阶段，部分功能可能与RNA结合蛋白(如参与RNA代谢)相关，需结合具体实验验证。
RALYL (RALY RNA-binding protein-like) is a human protein encoded by the *RALYL* gene, which shares homology with the RALY protein, a member of the RNA-binding RRM (RNA recognition motif) family. While its precise biological functions remain under investigation, RALYL is implicated in RNA metabolism, including splicing, stability, and translation regulation. Studies suggest it interacts with RNA molecules and protein complexes to modulate gene expression at post-transcriptional levels. Structurally, RALYL contains conserved RRM domains essential for RNA binding.
RALYL gained attention due to its potential role in development and disease. Research links it to neurodevelopment, with mouse studies indicating involvement in cortical layer formation. Aberrant RALYL expression has been observed in cancers, such as hepatocellular carcinoma and lung adenocarcinoma, where it may act as an oncogenic factor by promoting cell proliferation or suppressing apoptosis.
Recombinant RALYL protein, produced via bacterial or eukaryotic expression systems, enables in vitro studies on its RNA-binding properties, interactome mapping, and mechanistic insights into its cellular roles. Antibodies against recombinant RALYL facilitate localization and expression analysis in tissues. Despite progress, comprehensive functional models and clinical relevance require further exploration. Its dual roles in development and malignancy highlight RALYL as a compelling target for biomedical research.
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