| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RPL38 |
| Uniprot No | P63173 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-70 aa |
| 活性数据 | PRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL PPGLAVKELK |
| 分子量 | 8.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RPL38蛋白的3篇参考文献示例：
1. **"Recombinant Human RPL38 Structural Characterization and Ribosome Assembly Role"**
*Zhang et al. (2020)*
本研究通过重组表达技术纯化人RPL38蛋白，结合X射线晶体学解析其三维结构，揭示了其在核糖体大亚基组装中的关键相互作用位点，为核糖体生物发生机制提供了新见解。
2. **"RPL38-Mediated Translational Control of Hox Genes in Mammalian Development"**
*Barna et al. (2015)*
利用重组RPL38蛋白功能回补实验，证明其在胚胎发育中通过选择性调控Hox mRNA的翻译影响体轴形成，突变导致小鼠模型骨骼发育异常，突显核糖体蛋白的翻译特异性调控功能。
3. **"Recombinant RPL39L and RPL38 as Biomarkers in Triple-Negative Breast Cancer"**
*Chu et al. (2018)*
通过分析重组RPL38与其同源蛋白RPL39L的差异表达，发现两者在乳腺癌细胞中异常调控肿瘤生长和转移，提示其作为潜在治疗靶点的价值。
注：以上文献信息为模拟示例，实际引用需根据具体研究查询真实文献。
Ribosomal protein L38 (RPL38), a component of the 60S large ribosomal subunit, plays a critical role in protein synthesis by facilitating ribosome assembly and translation fidelity. Encoded by the RPL38 gene in humans, this highly conserved protein consists of 70 amino acids and is essential for cellular viability. Beyond its canonical ribosomal function, RPL38 has been implicated in tissue-specific translational regulation, particularly in developmental processes. Studies suggest it may influence the expression of specific mRNAs, such as those encoding Hox genes, through ribosome-mediated mechanisms, thereby affecting embryonic patterning and morphogenesis. Dysregulation of RPL38 has been associated with developmental disorders and cancers, highlighting its potential role in disease pathogenesis. Recombinant human RPL38 is typically produced using bacterial or mammalian expression systems, enabling biochemical studies and functional characterization. Its applications span structural analysis of ribosomes, investigation of ribosomopathies, and exploration of context-dependent translational control mechanisms. As research progresses, RPL38 continues to emerge as a molecular nexus linking ribosomal function to specialized cellular programs, offering insights into both basic biology and therapeutic targeting.
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