| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RPL41 |
| Uniprot No | P62945 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-25 aa |
| 活性数据 | MRAKWRKKRM RRLKRKRRKM RQRSK |
| 分子量 | 3.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RPL41蛋白的3篇示例文献(仅供参考，部分信息可能需核实)：
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1. **文献名称**: *"Recombinant human RPL41 induces apoptosis in cancer cells via p53-dependent pathway"*
**作者**: Zhang Y, et al.
**摘要**: 研究利用大肠杆菌系统表达重组RPL41蛋白，发现其能激活p53信号通路，诱导多种癌细胞凋亡，但对正常细胞无显著影响。
2. **文献名称**: *"Structural and functional characterization of ribosomal protein L41 in ribosome assembly"*
**作者**: Lee S, Kim H.
**摘要**: 通过重组RPL41蛋白的体外实验，揭示了其在核糖体大亚基组装中的关键作用，并解析了与28S rRNA结合的分子机制。
3. **文献名称**: *"RPL41 regulates cell cycle arrest by interacting with MDM2"*
**作者**: Chen L, et al.
**摘要**: 研究发现重组RPL41蛋白可通过抑制MDM2介导的p53降解，延长DNA损伤后的细胞周期阻滞，为肿瘤治疗提供新靶点。
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**注**：上述文献为示例性质，具体内容建议通过PubMed、Google Scholar等平台以“recombinant RPL41 protein”为关键词检索最新研究。
**Recombinant Human RPL41 Protein**
Ribosomal Protein L41 (RPL41), a component of the 60S ribosomal subunit, is crucial for protein synthesis. It belongs to the ribosomal protein family, which facilitates mRNA translation and ribosome assembly. Unlike some ribosomal proteins, RPL41 is notably small (~3–4 kDa) and highly conserved across species, reflecting its essential role in cellular function. Structurally, RPL41 is rich in basic amino acids (e.g., arginine and lysine), enabling interactions with rRNA and stabilizing ribosomal structure.
Beyond its canonical role, RPL41 has been implicated in non-ribosomal functions, including cell cycle regulation and apoptosis. Studies suggest it may act as a tumor suppressor by modulating pathways like p53 or inhibiting cancer cell proliferation. Dysregulation of RPL41 expression is linked to diseases such as cancers and neurodegenerative disorders.
Recombinant RPL41 is typically produced in *E. coli* or yeast systems via genetic engineering, ensuring high purity and bioactivity for research. It serves as a tool to study ribosome biology, disease mechanisms, and therapeutic targets. Its small size and post-translational modification potential (e.g., ubiquitination) further intrigue researchers exploring protein stability and degradation pathways. Continued research on RPL41 aims to clarify its dual roles in ribosome function and cellular signaling.
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