| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RPS17 |
| Uniprot No | P08708 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-135 aa |
| 活性数据 | GRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT QPTVGMNFKT PRGPV |
| 分子量 | 15.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RPS17蛋白的3篇示例参考文献及摘要概括(文献为假设性示例，供参考)：
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1. **文献名称**: *Recombinant Human RPS17 Promotes Ribosome Biogenesis and Correlates with Cell Proliferation in vitro*
**作者**: Zhang, Y. et al.
**摘要**: 本研究通过在大肠杆菌中重组表达人RPS17蛋白，验证其对核糖体生物合成的调控作用。实验表明，外源性RPS17可加速HEK293细胞的核糖体RNA加工，并通过激活mTOR通路促进细胞增殖，提示其在癌症发展中的潜在作用。
2. **文献名称**: *Structural and Functional Analysis of RPS17 Mutations Associated with Diamond-Blackfan Anemia*
**作者**: Smith, J. et al.
**摘要**: 通过体外重组表达携带DBA(先天性纯红细胞再生障碍性贫血)相关突变的RPS17变体蛋白，发现部分突变(如R62Q)导致蛋白与18S rRNA的结合能力下降，破坏核糖体组装，阐明了RPS17缺陷引发红细胞发育异常的分子机制。
3. **文献名称**: *Development of a High-Yield RPS17 Protein Production System Using Pichia pastoris*
**作者**: Lee, H. & Kim, S.
**摘要**: 报道了一种在毕赤酵母中高效表达重组人RPS17蛋白的方法，优化后蛋白产量达120 mg/L。纯化的RPS17可用于单克隆抗体制备，为后续疾病诊断试剂开发提供了基础。
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**备注**: 实际文献需通过PubMed等数据库检索关键词“RPS17”“recombinant”等获取，建议结合具体研究方向筛选近年高影响力论文。
Ribosomal Protein S17 (RPS17) is a key component of the 40S small subunit of eukaryotic ribosomes, essential for mRNA translation and protein synthesis. As part of the ribosomal complex, RPS17 contributes to ribosome assembly, stability, and accurate decoding of genetic information. The human RPS17 gene, located on chromosome 15. encodes a highly conserved 155-amino-acid protein with a central RNA-binding domain critical for rRNA interaction. Beyond its canonical role in translation, RPS17 has been implicated in extraribosomal functions, including cell cycle regulation, apoptosis, and DNA repair, with dysregulation linked to diseases such as Diamond-Blackfan anemia (DBA), a ribosomopathy characterized by mutations in ribosomal protein genes. Recent studies also suggest its potential involvement in cancer progression, as abnormal RPS17 expression has been observed in certain malignancies. Recombinant human RPS17. typically produced in *E. coli* or mammalian expression systems, serves as a vital tool for structural studies, ribosome biogenesis research, and investigating molecular mechanisms underlying RPS17-related pathologies. Its purity and bioactivity enable applications in drug discovery, functional assays, and exploring therapeutic strategies targeting ribosomal dysfunction. Ongoing research continues to unravel its multifaceted roles in cellular homeostasis and disease.
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