关键信息
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基因名
RDM1
- 应用
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别名
MGC33977; RAD52 homolog B; RAD52 motif 1; RAD52 motif containing 1; RAD52 motif-containing protein 1; RAD52B; RDM1; RDM1_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NG50
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表达区间
1-284 aa
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氨基酸序列
MAELVPFAVP IESDKTLLVW ELSSGPTAEA LHHSLFTAFS QFGLLYSVRV FPNAAVAHPG FYAVIKFYSA RAAHRAQKAC DRKQLFQKSP VKVRLGTRHK AVQHQALALN SSKCQELANY YFGFNGCSKR IIKLQELSDL EERENEDSMV PLPKQSLKFF CALEVVLPSC DCRSPGIGLV EEPMDKVEEG PLSFLMKRKT AQKLAIQKAL SDAFQKLLIV VLESGKIAVE YRPSEDIVGV RCEEELHGLI QVPCSPWKQY GQEEEGYLSD FSLEEEEFRL PELD
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分子量
31.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RDM1, a protein implicated in DNA damage repair, has garnered significant attention due to its role in maintaining genomic stability. It is particularly vital in the context of homologous recombination, a critical mechanism for repairing double-strand breaks in DNA. Research indicates that RDM1 interacts with various proteins involved in the DNA repair pathway, suggesting its function as a scaffold that orchestrates repair processes. Mutations or dysregulation of RDM1 have been associated with various cancers and genetic disorders, underscoring its importance in tumorigenesis and cellular response to genotoxic stress. The study of RDM1 and its recombinant forms can provide insights into the fundamental mechanisms of DNA repair and its implications in cancer biology. Furthermore, understanding the structure and function of RDM1 could lead to the development of novel therapeutic strategies aimed at enhancing DNA repair mechanisms in cancer cells, potentially improving the efficacy of existing treatments. Hence, research on RDM1 not only contributes to the foundational knowledge of cellular repair mechanisms but also opens new avenues for therapeutic interventions in cancer and other diseases linked to DNA repair dysfunction.
