| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RUNDC3B |
| Uniprot No | Q96NL0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-473 aa |
| 活性数据 | MASRSLGGLS GIRGGGGGGG KKSLSARNAA VERRNLITVC RFSVKTLIDR SCFETIDDSS PEFNNFAAIL EQILSHRLKE ISQSCRWLAH LQIPLQGQVT WFGYESPRSF WDYIRVACRK VSQNCICSIE NMENVSSSRA KGRAWIRVAL MEKHLSEYIS TALRDFKTTR RFYEDGAIVL GEEANMLAGM LLGLNAIDFS FCLKGEGLDG SFPAVIDYTP YLKYIQSSDS ISSDEEELRT LGSSGSESST PENVGPPFLM DENSWFNKCK RVKQKYQLTL EQKGYLEELL RLRENQLSES VSQNKILLQR IEDSDLAHKL EKEQLEYIIV ELQDQLTVLK NNDLRSRQEL TAHLTNQWPS PGALDVNAVA LDTLLYRKHN KQWYEKSYQS LDQLSAEVSL SQTSLDPGQS QEGDGKQDTL NVMSEGKEDT PSLLGLCGSL TSVASYKSLT SLKSNDYLAS PTTEMTSPGL TPS |
| 分子量 | 52.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是假设性的参考文献示例(注：以下内容基于模型推测，实际文献需通过学术数据库验证)：
1. **文献名称**: "RUNDC3B promotes lung adenocarcinoma progression by regulating EGFR signaling"
**作者**: Zhang, Y. et al. (2018)
**摘要**: 研究发现RUNDC3B通过增强EGFR信号通路的激活，促进肺癌细胞的增殖、迁移和侵袭，提示其作为潜在治疗靶点。
2. **文献名称**: "RUNDC3B modulates autophagy in neurodegenerative models"
**作者**: Wang, L. et al. (2020)
**摘要**: 揭示RUNDC3B通过与自噬相关蛋白(如LC3)相互作用，调控神经细胞自噬过程，可能参与阿尔茨海默病的病理机制。
3. **文献名称**: "High expression of RUNDC3B correlates with poor prognosis in gastric cancer"
**作者**: Li, H. et al. (2019)
**摘要**: 基于胃癌组织样本分析，RUNDC3B的高表达与肿瘤分期、转移及患者生存率下降显著相关，提示其作为预后标志物的潜力。
4. **文献名称**: "Structural insights into the RUN domain of RUNDC3B and its interaction with β-catenin"
**作者**: Tanaka, M. et al. (2021)
**摘要**: 通过晶体结构解析，阐明RUNDC3B的RUN结构域与β-catenin结合，激活Wnt信号通路，促进结直肠癌进展。
**备注**：以上为模型生成的假设性内容，实际研究中请查询权威数据库(如PubMed、Web of Science)获取真实文献。
RUNDC3B (RUN Domain Containing 3B) is a protein encoded by the RUNDC3B gene in humans, belonging to the RUN domain-containing protein family. The RUN domain is a conserved structural motif implicated in protein-protein interactions, particularly in signaling pathways and intracellular trafficking. RUNDC3B is predominantly expressed in neuronal tissues and has been linked to synaptic vesicle regulation, suggesting a potential role in neurotransmitter release and synaptic plasticity. Structurally, it interacts with Rab3 GTPases, which are critical mediators of exocytosis in neurons, possibly acting as an effector or regulator of Rab3 activity.
Recent studies highlight its involvement in cancer biology, where altered RUNDC3B expression correlates with tumor progression and metastasis in cancers such as breast and lung adenocarcinoma. Its tumor-suppressive or oncogenic role may depend on cellular context, with evidence suggesting it modulates cell proliferation, apoptosis, and cytoskeletal dynamics. Despite these associations, the precise molecular mechanisms and signaling networks involving RUNDC3B remain poorly characterized. Its subcellular localization, spanning cytoplasm and membrane-bound compartments, further underscores functional versatility. Research continues to explore its dual roles in neuronal physiology and cancer, aiming to clarify its diagnostic or therapeutic potential. Current data emphasize the need for deeper mechanistic studies to unravel its pathophysiological relevance across diseases.
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