| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SIPA1L2 |
| Uniprot No | Q9P2F8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 595-812 aa |
| 活性数据 | LLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDL |
| 分子量 | 31.9 kDa kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SIPA1L2蛋白的3-4篇参考文献的概括(基于假设性文献整理，仅供参考)：
---
1. **文献名称**: *"Recombinant Human SIPA1L2 Protein Suppresses Cancer Cell Invasion by Regulating Rap1 Activity"*
**作者**: Tanaka, R., et al.
**摘要**: 该研究通过表达和纯化重组人SIPA1L2蛋白，发现其通过抑制Rap1 GTP酶的活性，显著降低癌细胞的侵袭能力，提示SIPA1L2在肿瘤转移中的潜在治疗作用。
2. **文献名称**: *"Cloning, Expression, and Functional Analysis of SIPA1L2 in Neuronal Development"*
**作者**: Liu, Y., et al.
**摘要**: 研究者克隆了人源SIPA1L2基因，在大肠杆菌系统中成功表达重组蛋白，并发现其在神经元分化过程中通过调控细胞骨架重组促进突触形成。
3. **文献名称**: *"Interaction of SIPA1L2 with Microtubule-Associated Proteins: Implications for Axonal Transport"*
**作者**: Gupta, S., & Park, J.
**摘要**: 利用重组SIPA1L2蛋白进行体外结合实验，揭示其与微管相关蛋白MAP1B的相互作用，表明SIPA1L2可能通过影响轴突运输参与神经退行性疾病机制。
4. **文献名称**: *"Biophysical Characterization of the C-Terminal Domain of SIPA1L2 Reveals a Novel F-Actin Binding Motif"*
**作者**: Martinez, E., et al.
**摘要**: 通过重组表达SIPA1L2的C端结构域，发现其含有新型F-肌动蛋白结合基序，为解释SIPA1L2在细胞迁移和形态维持中的功能提供结构基础。
---
**说明**：上述文献为假设性示例，实际研究中请通过PubMed、Google Scholar等平台结合关键词“recombinant SIPA1L2”或“SIPA1L2 protein function”检索真实文献。若需具体文章，可进一步提供研究方向(如癌症、神经科学)以便精准查询。
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) is a member of the SIPA1 protein family, characterized by their shared Rap GTPase-activating protein (RapGAP) domains. Primarily expressed in the brain, SIPA1L2 plays roles in neuronal development, synaptic plasticity, and intracellular signaling regulation. Structurally, it contains PDZ and coiled-coil domains, facilitating protein-protein interactions critical for cytoskeletal organization and receptor clustering at synapses. Studies link SIPA1L2 to neurodevelopmental processes, including dendritic spine maturation and axonal guidance. Its RapGAP activity modulates Rap GTPase signaling pathways, influencing cell adhesion, migration, and polarity.
Emerging research associates SIPA1L2 with neurological disorders; mutations or dysregulation have been implicated in autism spectrum disorders and intellectual disability. Additionally, it may interact with psychiatric risk genes, suggesting broader relevance in mental health. Recombinant human SIPA1L2 protein, typically produced in mammalian or insect cell systems, serves as a tool for studying its biochemical properties, interaction networks, and therapeutic targeting. Its involvement in critical signaling cascades positions it as a potential biomarker or drug target for neurodevelopmental and neurodegenerative conditions. Further research is needed to fully elucidate its mechanisms and clinical implications.
×
