| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SMTNL2 |
| Uniprot No | Q2TAL5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-461 aa |
| 活性数据 | MEPAPDAQEA RTVREALGRY ELEGAVRA LHEDMRGLQR GVERRVAEAM RLAGPLARTV ADLQRDNQRL QAQLERLTRQ VEALGLASGM SPVPGTPGTP SPPPAPGVPD RAPRLGSARF ASHATFSLSG RGQSLDHDEA SESEMRKTSN SCIMENGHQP GAGPGDGPPE IAQNFSAPDP PRPRPVSLSL RLPHQPVTAI TRVSDRFSGE TSALSPMS TLGGLNPS PSEVITPWTP SPSEKNSSFT WSVPSSGYGA VTASKHSNSP PLVTPPQSPV SPQPPAITQV HRQGERRREL VRSQTLPRTS EAQARKALFE KWEQETGK GKGEARARLK RSQSFGVASA SSIKQILLEW CRSKTLGYQH VDLQNFSSSW SDGMAFCALV HSFFPDAFDY NSLSPTQRQK NFELAFTMAE NLANCERLIE VEDMMVMGRK PDPMCVFTYV QSLYNHLRRF E |
| 分子量 | 50.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为关于重组人SMTNL2蛋白的3篇代表性文献(模拟虚构示例，实际文献需查询数据库)：
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1. **文献名称**: "Recombinant SMTNL2 Regulates Smooth Muscle Contraction via Calcium Sensitization"
**作者**: Kim H, et al.
**摘要**: 研究通过大肠杆菌表达重组人SMTNL2蛋白，发现其通过抑制 RhoA/ROCK 通路降低钙敏感性，调节血管平滑肌收缩，可能成为高血压治疗靶点。
2. **文献名称**: "Structural Characterization of SMTNL2 and Its Interaction with Calmodulin"
**作者**: Zhang Y, et al.
**摘要**: 利用X射线晶体学解析SMTNL2结构，发现其含有CH结构域，并通过表面等离子共振(SPR)证实与钙调蛋白结合，提示其在细胞信号传导中的作用。
3. **文献名称**: "SMTNL2 Knockout Mice Exhibit Enhanced Insulin Sensitivity"
**作者**: Patel R, et al.
**摘要**: 体内实验表明，SMTNL2缺失导致肌肉GLUT4转运上调，重组蛋白注射可逆转代谢表型，提示其在胰岛素抵抗中的调控功能。
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提示：实际文献需通过 **PubMed/Google Scholar** 搜索关键词 "SMTNL2 recombinant protein" 获取，建议结合实验方向筛选近五年研究。
Smoothelin-like protein 2 (SMTNL2) is a cytoskeletal protein belonging to the smoothelin family, primarily expressed in smooth muscle tissues, skeletal muscle, and testis. It shares structural homology with smoothelin, containing two Calponin homology (CH) domains that mediate interactions with actin and other cytoskeletal components. SMTNL2 is implicated in regulating smooth muscle contraction and relaxation through mechanisms involving myosin phosphatase activity or calcium signaling modulation.
Research suggests its role in glucocorticoid signaling pathways, where it may act as an adaptor protein to influence cell proliferation, differentiation, and metabolic processes. Notably, SMTNL2 expression is altered in certain cancers, such as endometrial carcinoma, where it may function as a tumor suppressor. In reproductive biology, it has been linked to spermatogenesis and male fertility.
Recombinant SMTNL2 protein, produced via bacterial or eukaryotic expression systems, enables functional studies to dissect its biochemical properties, post-translational modifications (e.g., phosphorylation), and interactions with signaling molecules like RhoA or calmodulin. Its study provides insights into smooth muscle pathophysiology, hormone-regulated processes, and potential therapeutic targets for cardiovascular diseases, cancer, or fertility disorders. Current investigations also explore its diagnostic or prognostic biomarker potential in specific pathologies.
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