| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SNTB2 |
| Uniprot No | Q13425 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-540 aa |
| 活性数据 | MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL TGDAAAAELE PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP RGPAGEAGAS PPVRRVRVVK QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD LRQATHDQAV QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST KDRKIIPLKM CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE THRDLSSWTR ILVQGCHAAA ELIKEVSLGC MLNGQEVRLT IHYENGFTIS RENGGSSSIL YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV |
| 分子量 | 57.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SNTB2蛋白的3篇参考文献及其摘要概括：
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1. **文献名称**: "Crystal Structure of Human SNTB2 Reveals a Scaffolding Protein Involved in Membrane Organization"
**作者**: Lee, A.B. et al.
**摘要**: 本研究解析了重组人SNTB2蛋白的晶体结构，揭示了其PDZ结构域和pleckstrin同源(PH)结构域的空间排布。结果表明，SNTB2通过与膜结合蛋白的相互作用，参与细胞膜微结构域的组装及信号转导调控。
2. **文献名称**: "Recombinant SNTB2 Enhances Cancer Cell Invasion via Integrin Signaling Pathways"
**作者**: Zhang, Y. et al.
**摘要**: 通过体外表达重组SNTB2蛋白，研究证明其通过结合整合素β1亚基，激活FAK/Src信号通路，促进肿瘤细胞的迁移和侵袭，提示SNTB2在癌症转移中的潜在作用机制。
3. **文献名称**: "Expression and Functional Characterization of Recombinant Human SNTB2 in Neuronal Development"
**作者**: Brown, K.L. et al.
**摘要**: 本研究利用哺乳动物系统表达重组SNTB2蛋白，发现其与神经突触蛋白Synaptophysin存在互作，并在神经元突触形成中起关键调控作用，为神经发育障碍的研究提供新视角。
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上述文献方向涵盖结构解析、功能机制及表达应用，均为假设性示例，实际文献需通过学术数据库检索确认。
Syntrophin beta 2 (SNTB2) is a member of the syntrophin family, a group of cytoplasmic adapter proteins involved in organizing membrane-associated protein complexes. It contains a PDZ domain, a pleckstrin homology (PH) domain, and a syntrophin-unique (SU) domain, which mediate interactions with signaling molecules, ion channels, and cytoskeletal components. SNTB2 is ubiquitously expressed but notably enriched in tissues like skeletal muscle and brain, where it plays roles in cellular signaling, structural organization, and membrane stability.
Functionally, SNTB2 binds to dystrophin-associated protein complexes, facilitating the clustering of voltage-gated sodium channels and neuronal nitric oxide synthase (nNOS) at neuromuscular junctions. This interaction is critical for maintaining synaptic integrity and signal transduction. Dysregulation of SNTB2 has been implicated in neuromuscular disorders, including muscular dystrophies, and is studied in cancer for its potential role in metastasis through cytoskeletal remodeling.
Recombinant SNTB2 protein, typically produced in bacterial or mammalian expression systems, retains structural domains essential for binding partners. It is widely used in biochemical assays, structural studies, and drug discovery to explore its interaction networks and therapeutic targeting. Research continues to elucidate its regulatory mechanisms in health and disease.
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