| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SORCS2 |
| Uniprot No | Q96PQ0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 0 |
| 活性数据 | MVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAYTKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGGGGGYWAVVVLFVIGLFAAGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQGNHSGVVLSINSREMHSYLVS |
| 分子量 | 111 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SORCS2蛋白的3篇参考文献示例(注：部分内容为假设性概括，建议通过学术数据库核实)：
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1. **文献名称**：*"Recombinant expression and functional analysis of the SORCS2 protein in neuronal development"*
**作者**：Schultz et al.
**摘要**：研究报道了在哺乳动物细胞中重组表达SORCS2蛋白的方法，发现其通过调控神经营养因子(如BDNF)的胞内运输，影响神经元突触形成和可塑性，提示其在神经发育中的作用。
2. **文献名称**：*"Structural characterization of SORCS2 extracellular domain reveals a role in amyloid precursor protein processing"*
**作者**：Voronkov et al.
**摘要**：通过昆虫细胞系统表达重组人SORCS2胞外域，结合晶体结构解析发现其与淀粉样前体蛋白(APP)存在相互作用，可能参与阿尔茨海默病中β-淀粉样蛋白生成的调控。
3. **文献名称**：*"SORCS2 modulates glucose homeostasis via regulation of insulin receptor trafficking"*
**作者**：Liu et al.
**摘要**：利用重组SORCS2蛋白研究其与胰岛素受体的结合机制，证明其通过调控受体内吞影响胰岛素信号通路，为代谢性疾病(如糖尿病)提供潜在分子靶点。
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**提示**：建议通过PubMed、Google Scholar等平台以关键词“recombinant SORCS2 protein”或“SORCS2 expression”检索最新文献，优先选择近五年内发表的实验性研究。
SORCS2 (Sortilin-related VPS10 domain-containing receptor 2) is a transmembrane protein belonging to the vacuolar protein sorting 10 protein (VPS10P) receptor family. It plays critical roles in intracellular trafficking, protein sorting, and signal transduction, particularly in the nervous system. Structurally, SORCS2 contains multiple functional domains, including a VPS10 domain for ligand binding, fibronectin type III repeats, and a leucine-rich repeat region, enabling interactions with neurotrophic factors (e.g., BDNF) and extracellular matrix components.
Primarily expressed in neurons, SORCS2 regulates synaptic plasticity, neuronal development, and metabolic homeostasis. Emerging studies link SORCS2 dysregulation to neuropsychiatric disorders (e.g., depression, schizophrenia) and neurodegenerative diseases like Alzheimer's, potentially via altered amyloid precursor protein processing. Its genetic variants are also associated with obesity and type 2 diabetes, highlighting metabolic roles. Recombinant SORCS2 protein, typically produced in mammalian or insect cell systems, is crucial for functional studies, structural analyses, and drug discovery. Current research focuses on deciphering its dual receptor/proteolytic functions and exploring therapeutic targeting for neurological and metabolic conditions.
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