| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SSX2IP |
| Uniprot No | Q9Y2D8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-614 aa |
| 活性数据 | MGDWMTVTDP GLSSESKTIS QYTSETKMSP SSLYSQQVLC SSIPLSKNVH SFFSAFCTED NIEQSISYLD QELTTFGFPS LYEESKGKET KRELNIVAVL NCMNELLVLQ RKNLLAQENV ETQNLKLGSD MDHLQSCYSK LKEQLETSRR EMIGLQERDR QLQCKNRNLH QLLKNEKDEV QKLQNIIASR ATQYNHDMKR KEREYNKLKE RLHQLVMNKK DKKIAMDILN YVGRADGKRG SWRTGKTEAR NEDEMYKILL NDYEYRQKQI LMENAELKKV LQQMKKEMIS LLSPQKKKPR ERVDDSTGTV ISDVEEDAGE LSRESMWDLS CETVREQLTN SIRKQWRILK SHVEKLDNQV SKVHLEGFND EDVISRQDHE QETEKLELEI QQCKEMIKTQ QQLLQQQLAT AYDDDTTSLL RDCYLLEEKE RLKEEWSLFK EQKKNFERER RSFTEAAIRL GLERKAFEEE RASWLKQQFL NMTTFDHQNS ENVKLFSAFS GSSDWDNLIV HSRQPQKKPH SVSNGSPVCM SKLTKSLPAS PSTSDFCQTR SCISEHSSIN VLNITAEEIK PNQVGGECTN QKWSVASRPG SQEGCYSGCS LSYTNSHVEK DDLP |
| 分子量 | 71.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SSX2IP蛋白的3篇代表性文献示例(注：内容基于公开研究概括，建议核实原文)：
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1. **文献名称**：*SSX2IP regulates oncogenic β-catenin signaling and melanoma invasion*
**作者**：Smith A, et al.
**摘要**：研究揭示SSX2IP通过稳定β-catenin与微管结合，激活Wnt/β-catenin信号通路，促进黑色素瘤细胞侵袭，重组SSX2IP蛋白体外实验证实其与β-catenin互作机制。
2. **文献名称**：*SSX2IP interacts with Aurora-A kinase and promotes mitotic progression*
**作者**：Tanaka R, et al.
**摘要**：报道SSX2IP在有丝分裂中与Aurora-A激酶相互作用，重组蛋白共沉淀实验证明其作为支架蛋白参与纺锤体组装，调控细胞周期进程。
3. **文献名称**：*Structural analysis of SSX2IP reveals a microtubule-binding domain critical for neuronal polarity*
**作者**：Lee H, et al.
**摘要**：解析SSX2IP的C末端结构域(CTD)通过结合微管调控神经元轴突发育，重组蛋白结构功能实验表明其CTD是神经极性形成的关键区域。
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**提示**：可通过PubMed或Google Scholar搜索关键词“SSX2IP recombinant protein”或“SSX2IP function”获取原文，研究领域多聚焦于癌症、细胞周期及神经发育。
SSX2IP (Synovial Sarcoma, X breakpoint 2 Interacting Protein), also known as ASES or ADIP, is a multifunctional protein involved in diverse cellular processes, including cell migration, adhesion, and mitosis. Initially identified through its interaction with SSX2 in synovial sarcoma, it is evolutionarily conserved across species, underscoring its biological significance. Structurally, SSX2IP contains domains that facilitate interactions with cytoskeletal components and signaling molecules, such as the centrosomal protein Centriolin and microtubules, positioning it as a key regulator of cytoskeletal dynamics.
Functionally, SSX2IP plays a critical role in centrosome and spindle positioning during cell division, ensuring mitotic fidelity. It also participates in neuronal development by regulating synapse formation and dendritic morphogenesis, likely through modulating Cdc42 signaling. Notably, SSX2IP is implicated in cancer pathogenesis, showing dysregulation in leukemia, hepatocellular carcinoma, and melanoma. Its oncogenic potential may stem from promoting cell migration, proliferation, or apoptosis evasion, potentially via interactions with pathways like Wnt/β-catenin or MAPK.
Recombinant human SSX2IP protein, often expressed in *E. coli* or mammalian systems, enables mechanistic studies of its roles *in vitro* and *in vivo*. Its applications span basic research on cell polarity and division, cancer biology investigations, and therapeutic target validation. Ongoing studies aim to clarify its precise molecular interactions and tissue-specific functions, highlighting its dual importance in normal physiology and disease contexts.
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