| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | STAG3L1 |
| Uniprot No | P0CL83 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-205 aa |
| 活性数据 | MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG WTLHDKHREV RVKCVKALKG LYGNRDLTAR LELFTGRFKD WMVSMIVDRE YSVAVEAVRL LILILKLFYP ECEIRTMGGR EQRQSPGAQR TFFQLLLSFF VESKLHDHAA YLVDNLWDCA GTQLKDWEGL TSLLLEKDQS TCHMEPGPGT FHLLG |
| 分子量 | 23.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人STAG3L1蛋白的3篇代表性文献摘要(注：经核实，部分文献信息需结合实际情况修正，以下内容为模拟示例)：
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1. **文献名称**：*STAG3L1 is a novel component of the cohesin complex involved in chromosome segregation*
**作者**：Smith A, et al.
**摘要**：该研究首次揭示STAG3L1作为粘连蛋白(cohesin)复合体的亚基，与SMC1/3蛋白相互作用，参与有丝分裂中染色体的正确分离，敲除STAG3L1会导致染色体不稳定性。
2. **文献名称**：*Expression profiling of STAG3L1 in human germ cells and its role in meiosis*
**作者**：Li J, et al.
**摘要**：通过免疫组化与RNA干扰实验，发现STAG3L1在人类睾丸生殖细胞中高表达，调控减数分裂同源染色体配对过程，其功能缺失可能引发男性不育。
3. **文献名称**：*STAG3L1 promotes tumor metastasis via regulating epithelial-mesenchymal transition in breast cancer*
**作者**：Zhang Y, et al.
**摘要**：该研究证明STAG3L1在乳腺癌中异常高表达，通过激活TGF-β信号通路促进上皮间质转化(EMT)，增强癌细胞侵袭能力，提示其作为癌症治疗靶点的潜力。
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**注意**：以上文献为基于公开研究领域的模拟示例，实际研究中需通过PubMed等数据库检索最新文献。若需具体文献，建议使用关键词“STAG3L1”或“stromal antigen 3-like 1”在学术平台查询。
The stromal antigen 3-like 1 (STAG3L1) protein is a member of the STAG family, which are integral components of the cohesin complex involved in chromosome organization, DNA repair, and transcriptional regulation. STAG3L1 shares structural homology with STAG3. a meiosis-specific cohesin subunit critical for sister chromatid cohesion during gametogenesis. While STAG3 is predominantly expressed in germ cells, STAG3L1 exhibits broader tissue expression, suggesting potential roles beyond meiosis. The protein contains conserved STAG domains that mediate interactions with other cohesin subunits like SMC1/3 and RAD21. facilitating chromatin binding.
Functionally, STAG3L1 is implicated in maintaining genomic stability, though its precise mechanisms remain less characterized compared to other STAG paralogs. Studies suggest it may act as a regulatory partner or backup for STAG3. particularly in somatic cells. Dysregulation of STAG proteins is linked to developmental disorders and cancers, with STAG3L1 mutations occasionally observed in tumor genomes. Recombinant human STAG3L1 (produced via heterologous expression systems) serves as a tool for studying cohesin dynamics, protein interactions, and its role in chromatin architecture. Current research focuses on elucidating its contribution to cellular processes and potential therapeutic relevance in cohesionopathies or malignancies.
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