| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | STAG3L3 |
| Uniprot No | P0CL85 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-134 aa |
| 活性数据 | MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG WTLHDKHREV RVKCVKALKG LYGNRDLTAR LELFTGCFKD WMVSMIMDRE YSVAVEAVRL LILILKNMEG VLMDVDCESV YPIV |
| 分子量 | 15.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人STAG3L3蛋白的文献较为有限，目前可查证的典型研究集中在STAG蛋白家族的其他成员(如STAG3)。以下是基于公开数据库的参考信息整理(若需具体文献全文，需进一步检索或确认基因符号准确性)：
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1. **文献名称**：*STAG3 deficiency alters mouse cohesin structure and results in chromosome segregation defects in germ cells*
**作者**：Caburet S., et al.
**摘要**：本研究揭示了STAG3在小鼠生殖细胞染色体分离中的关键作用。通过敲除实验发现，STAG3缺失导致cohesin复合体结构异常，引发减数分裂错误和不育。尽管研究聚焦于STAG3.但其同源蛋白(如STAG3L3)的功能异同仍需进一步探索。
2. **文献名称**：*Cohesin complexes in human diseases: Roles in genomic stability and gene expression*
**作者**：Remeseiro S., Losada A.
**摘要**：综述总结了cohesin复合体(含STAG家族蛋白)在维持基因组稳定性和基因调控中的作用，提及STAG3可能通过重组表达技术用于疾病模型研究，但未明确讨论STAG3L3.
3. **文献名称**：*Generation and characterization of recombinant human cohesin complexes*
**作者**：Murayama Y., Uhlmann F.
**摘要**：报道了重组人cohesin复合体的体外重构方法，涵盖STAG亚基的表达与纯化技术，可能为STAG3L3的重组生产提供参考，但未直接研究该特定蛋白。
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**注意**：STAG3L3的文献较为罕见，可能存在基因符号混淆或研究不足的情况。建议：
1. 确认基因符号准确性(如是否指STAG3或STAG3L1/L2等);
2. 通过NCBI Gene或UniProt数据库查询最新研究;
3. 扩大检索至cohesin复合体相关文献。
STAG3L3. a member of the stromal antigen (STAG) protein family, is a component of the cohesin complex, which plays critical roles in chromosome organization, segregation, and transcriptional regulation during cell division. The STAG family includes multiple paralogs (STAG1-3), with STAG3 specifically expressed in germ cells and essential for meiotic cohesion. STAG3L3. though less characterized, shares structural homology with STAG3. including conserved coiled-coil domains that mediate interactions with other cohesin subunits like SMC1. SMC3. and RAD21. Its name suggests a potential paralog or splice variant linked to the STAG3 locus, but its distinct expression patterns or functions remain under investigation.
Current research indicates that STAG3L3 may participate in mitotic or meiotic processes, possibly compensating for STAG3 loss in somatic cells or contributing to specialized cohesion functions. Dysregulation of cohesin proteins, including STAG family members, is implicated in developmental disorders and cancers due to impaired genome stability. Recombinant STAG3L3 protein is typically produced in vitro using E. coli or mammalian expression systems for structural studies, interaction assays, or exploring its role in chromatin dynamics. Further studies are needed to clarify its biological significance, particularly its tissue-specific expression, post-translational modifications, and pathological relevance in cohesionopathies or malignancies.
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