| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TCF19 |
| Uniprot No | Q9Y242 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-345 aa |
| 活性数据 | MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP GLISGIHAEL HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM FQQVRVKPQD FAAITIPRSR GEARVGAGFR PMLPSQGAPQ RPLSTFSPAP KATLILNSIG SLSKLRPQPL TFSPSWGGPK SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP PENPPPVLME PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT |
| 分子量 | 37.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TCF19蛋白的3篇参考文献列表(基于近期研究方向的模拟整理)：
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1. **文献名称**：**"TCF19 Regulates Cell Cycle Progression Through Modulation of Chromatin Accessibility in Hepatocellular Carcinoma"**
**作者**：Zhang Y, et al.
**摘要**：该研究揭示了TCF19作为转录因子在肝细胞癌中的功能，通过重组表达TCF19蛋白验证其与染色质调控因子的相互作用，证明其通过调控靶基因的染色质开放状态促进癌细胞周期进程。
2. **文献名称**：**"Structural and Functional Characterization of Recombinant Human TCF19 in Type 1 Diabetes Susceptibility"**
**作者**：Smith JL, et al.
**摘要**：本研究利用大肠杆菌系统表达并纯化重组TCF19蛋白，结合晶体学分析其结构，探讨了TCF19基因多态性与1型糖尿病易感性的关联，揭示了其通过NF-κB通路调控免疫反应的分子机制。
3. **文献名称**：**"Recombinant TCF19 Protein as a Potential Biomarker for Prostate Cancer Progression"**
**作者**：Gupta R, et al.
**摘要**：通过临床样本分析，研究发现前列腺癌患者血清中TCF19蛋白水平显著升高。实验利用重组TCF19验证其促进肿瘤细胞迁移和侵袭的功能，提出其作为新型液体活检标志物的可能性。
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*注：以上文献为示例，实际引用请根据具体研究方向通过PubMed或Web of Science检索真实论文。如需全文获取或进一步整理，请提供更多细节。*
**Background of Recombinant Human TCF19 Protein**
TCF19 (Transcription Factor 19) is a nuclear protein encoded by the *TCF19* gene, implicated in transcriptional regulation, cell cycle control, and immune response modulation. Structurally, it contains domains such as the PHD zinc finger and SCAN domain, suggesting roles in chromatin remodeling and protein-protein interactions. TCF19 is highly expressed in proliferating cells and tissues like the pancreas, thymus, and immune cells, indicating its importance in cellular homeostasis and development.
Recombinant human TCF19 protein, produced via expression systems like *E. coli* or mammalian cells, retains functional properties for research applications. It is used to study mechanisms underlying diseases such as cancer, autoimmune disorders, and diabetes. For instance, TCF19 has been linked to pancreatic β-cell apoptosis and regeneration, highlighting its potential role in type 1 diabetes.
Mechanistically, TCF19 interacts with proteins involved in cell cycle checkpoints (e.g., p53 pathway) and inflammatory signaling (e.g., NF-κB), making it a candidate for therapeutic targeting. Its genetic variants are associated with autoimmune diseases, emphasizing clinical relevance. However, its precise molecular functions remain under investigation, necessitating further studies using recombinant TCF19 to clarify its biological and pathological roles.
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