| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TEX10 |
| Uniprot No | Q9NXF1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-929 aa |
| 活性数据 | MTKKRKRQHDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQLKEDGTLPTNNRKLNIKDLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVFTDKDANVRLAAVQLLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQEDSLKVLDILLEQYPALITGRSSILLKNFVELISHQQLSKGLINRDRSQSWILSVNPNRRLTSQQWRLKVLVRLSKFLQALADGSSRLRESEGLQEQKENPHATSNSIFINWKEHANDQQHIQVYENGGSQPNVSSQFRLRYLVGGLSGVDEGLSSTENLKGFIEIIIPLLIECWVEAVPPQLATPVGNGIEREPLQVMQQVLNIISLLWKLSKQQDETHKLESWLRKNYLIDFKHHFMSRFPYVLKEITKHKGKEPNKSIKHCTVLSNNIDHLLLNLTLSDIMVSLANASTLQKDCSWIEMIRKFVTETLEDGSRLNSKQLNRLLGVSWRLMQIQPNREDTETLIKAVYTLYQQRGLILPVRTLLLKLFSKIYQTEELRSCRFRYRSKVLSRWLAGLPLQLAHLGSRNPELSTQLIDIIHTAAARANKELLKSLQATALRIYDPQEGAVVVLPADSQQRLVQLVYFLPSLPADLLSRLSRCCIMGRLSSSLAAMLIGILHMRSSFSGWKYSAKDWLMSDVDYFSFLFSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYLTDLDQFLHHWDVTEAVFHSLLVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVICKLLDHTCVVSETLLPFLASCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILALLPRVLRLMLQSLRVNRVGPEELPVVGQLLRLLLQHAPLRTHMLTNAILVQQIIKNITTLKSGSVQEQWLTDLHYCFNVYITGHPQGPSALATVY |
| 分子量 | 131.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TEX10蛋白的模拟参考文献示例(仅供格式参考，非真实文献)：
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1. **文献名称**: *Structural Insights into the Role of TEX10 in RNA Splicing Complexes*
**作者**: Yamamoto, A. et al.
**摘要**: 本研究通过冷冻电镜解析了重组人TEX10蛋白与剪接体核心组件的复合物结构，揭示其通过C端结构域结合RNA，调控pre-mRNA剪接的分子机制。
2. **文献名称**: *TEX10 Interaction with the NLRP3 Inflammasome Pathway*
**作者**: Chen, L. & Smith, R.
**摘要**: 利用免疫共沉淀技术，发现重组TEX10蛋白与NLRP3炎症小体组分存在物理相互作用，敲低TEX10显著抑制炎症因子释放，提示其在先天免疫中的新功能。
3. **文献名称**: *TEX10 Knockout Models Reveal Embryonic Lethality and Cancer Association*
**作者**: Gupta, S. et al.
**摘要**: 通过CRISPR构建的TEX10基因敲除小鼠模型显示胚胎致死表型，结合肝癌组织样本分析，发现TEX10表达失调与基因组不稳定性及肿瘤进展相关。
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**提示**：实际文献需通过PubMed、Web of Science或Google Scholar检索(关键词：TEX10. recombinant protein, function)。建议结合最新研究筛选高影响力论文。
**Background of Recombinant Human TEX10 Protein**
The TEX10 (Testis-expressed protein 10) gene encodes a conserved eukaryotic protein implicated in transcriptional regulation, chromatin remodeling, and DNA damage repair. As a member of the nuclear pore complex-associated (NPAC) family, TEX10 interacts with critical transcriptional regulators, including components of the SAGA (Spt-Ada-Gcn5-acetyltransferase) complex, which is essential for histone modification and RNA polymerase II-mediated transcription. Studies suggest TEX10 is a scaffold protein that stabilizes interactions within multi-protein assemblies, such as the XAB2 complex, coordinating transcription-coupled DNA repair and pre-mRNA splicing.
TEX10 plays a role in maintaining genomic stability by participating in homology-directed repair (HDR) of DNA double-strand breaks. Dysregulation of TEX10 is linked to cancer progression, as its overexpression has been observed in prostate, breast, and liver cancers, correlating with poor prognosis and therapeutic resistance. In germ cells, TEX10 is critical for meiotic progression and spermatogenesis, reflecting its conserved function in cell cycle regulation.
Recombinant human TEX10 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), serves as a tool to study its molecular interactions, structural features, and functional roles in vitro. Its applications include investigating DNA repair mechanisms, chromatin dynamics, and developing targeted therapies for cancers with TEX10-associated pathways.
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