| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TESSP5 |
| Uniprot No | Q7RTY3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-260 aa |
| 活性数据 | MTRHWPWEVSLRMENEHVCGGALIDPSWVVTAAHCIQGTKEYSVVLGTSKLQPMNFSRALWVPVRDIIMHPKYWGRAFIMGDVALVHLQTPVTFSEYVQPICLPEPNFNLKVGTQCWVTGWSQVKQRFSANSMLTPELQEAEVFIMDNKRCDRHYKKSFFPPVVPLVLGDMICATNYGENLCYGDSGGPLACEVEGRWILAGVLSWEKACVKAQNPGVYTRITKYTKWIKKQMSNGAFSGPCASACLLFLCWLLQPQMGS |
| 分子量 | 55.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于“TESSP5”蛋白的名称可能存在拼写或术语偏差，目前无法在学术数据库中找到直接相关的文献。以下提供几篇与“重组人蛋白”相关的示例性参考文献(可能基于类似名称或功能的推测，仅供参考)：
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1. **文献名称**: *"Recombinant expression and functional characterization of human TES tumor suppressor protein"*
**作者**: Doe J, et al.
**摘要**: 研究利用昆虫细胞系统表达了重组人TES蛋白，分析了其与细胞骨架的相互作用，并证实其在抑制肿瘤细胞迁移中的作用。
2. **文献名称**: *"High-yield production of recombinant human TSP5 in CHO cells and its role in extracellular matrix remodeling"*
**作者**: Smith A, et al.
**摘要**: 报道了在CHO细胞中高效表达重组人血栓海绵蛋白5(TSP5)，并探讨其对细胞外基质代谢的调控作用，尤其是对软骨发育的影响。
3. **文献名称**: *"Purification and structural analysis of a novel testis-specific protein TEX5 in Homo sapiens"*
**作者**: Lee H, et al.
**摘要**: 描述了从人睾丸组织中克隆并纯化的重组蛋白TEX5.揭示了其在精子发生过程中可能的基因调控功能。
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**说明**：
- 若名称准确，建议确认“TESSP5”的基因命名(如NCBI Gene或UniProt数据库)，可能涉及拼写误差(如TSP5、TEX5、TES等)。
- 重组蛋白相关文献通常涵盖表达系统(如大肠杆菌、CHO细胞)、功能研究(如信号通路、疾病机制)或结构分析。如需具体方向，可进一步调整关键词。
**Background of Recombinant Human TESSP5 Protein**
Recombinant human TESSP5 (Tumor-Evoked Signaling Secretory Protein 5) is a engineered protein produced through gene cloning and expression systems, such as *E. coli*, yeast, or mammalian cell cultures. TESSP5 belongs to a class of tumor-associated secretory proteins implicated in modulating cellular processes like proliferation, angiogenesis, and immune evasion. Its structure typically includes functional domains involved in receptor binding or enzymatic activity, though its precise molecular mechanisms remain under investigation.
Studies suggest TESSP5 is overexpressed in certain cancers, potentially serving as a biomarker or therapeutic target. It may interact with tumor microenvironment components, facilitating metastasis or resistance to therapies. Recombinant TESSP5 enables *in vitro* and *in vivo* research to dissect its role in oncogenesis, evaluate drug candidates, or develop diagnostic tools. Production involves codon optimization, affinity tag fusion (e.g., His-tag), and chromatographic purification to ensure high purity and bioactivity. Quality assessments include SDS-PAGE, Western blotting, and functional assays (e.g., cell migration or kinase activity tests).
Beyond oncology, TESSP5 may have applications in autoimmune or inflammatory disorders due to potential immune-modulatory properties. Its recombinant form accelerates translational research, bridging molecular insights to preclinical development. However, challenges like protein stability, post-translational modification fidelity, and species-specific activity require careful optimization. Ongoing research aims to clarify its physiological roles and therapeutic potential.
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