| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF305 |
| Uniprot No | O43309 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-604 aa |
| 活性数据 | MASTWAIQAH MDQDEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQETV RLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS EEMEPHGKTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSHLI EHQRIHTGDR PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF RRDL |
| 分子量 | 70.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF305蛋白的3篇参考文献及其摘要简述：
1. **文献名称**：*ZNF305 regulates the proliferation and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway*
**作者**：Li X, et al.
**摘要**：本研究揭示ZNF305通过调控MAPK信号通路促进肝癌细胞增殖并抑制凋亡，可能成为肝癌治疗的潜在靶点。
2. **文献名称**：*The role of ZNF305 in modulating innate immune responses to viral infection*
**作者**：Wang Y, et al.
**摘要**：该文献发现ZNF305蛋白通过抑制RIG-I样受体通路负向调节宿主抗病毒免疫反应，影响干扰素的产生。
3. **文献名称**：*Structural and functional analysis of zinc finger protein ZNF305 reveals DNA-binding specificity*
**作者**：Kumar R, et al.
**摘要**：通过晶体结构解析，阐明ZNF305蛋白通过第2-4锌指结构域特异性识别富含GC的DNA序列，参与基因转录调控。
注：上述文献信息为模拟示例，实际研究中建议通过PubMed或Web of Science查询真实文献。
Zinc finger protein 305 (ZNF305) is a member of the zinc finger protein family, characterized by conserved C2H2-type zinc finger domains that mediate DNA binding and protein-protein interactions. It is encoded by the *ZNF305* gene located on human chromosome 19 and is evolutionarily conserved across vertebrates, suggesting essential biological roles. While the full functional spectrum of ZNF305 remains under investigation, studies link it to immune regulation, apoptosis, and transcriptional control. Notably, ZNF305 has been implicated in modulating antigen receptor diversification in lymphocytes, particularly through interaction with recombination signal sequences, which may influence V(D)J recombination efficiency. In cancer biology, ZNF305 exhibits context-dependent roles, acting as a potential tumor suppressor in some malignancies by promoting apoptosis or restraining proliferation, while paradoxically showing oncogenic features in others. Its dysregulation has been associated with autoimmune diseases and certain cancers. Recombinant ZNF305 protein, typically produced via bacterial or mammalian expression systems, enables mechanistic studies of its DNA-binding properties, interactions with partner proteins (e.g., nucleases or chromatin remodelers), and functional screens. Current research focuses on clarifying its precise molecular targets, signaling pathways, and therapeutic potential in immune disorders or oncology.
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