| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF397 |
| Uniprot No | Q8NF99 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-534 aa |
| 活性数据 | MAVESGVIST LIPQDPPEQE LILVKVEDNF SWDEKFKQNG STQSCQELFR QQFRKFCYQE TPGPREALSR LQELCYQWLM PELHTKEQIL ELLVLEQFLS ILPEELQIWV QQHNPESGEE AVTLLEDLER EFDDPGQQVP ASPQGPAVPW KDLTCLRASQ ESTDIHLQPL KTQLKSWKPC LSPKSDCENS ETATKEGISE EKSQGLPQEP SFRGISEHES NLVWKQGSAT GEKLRSPSQG GSFSQVIFTN KSLGKRDLYD EAERCLILTT DSIMCQKVPP EERPYRCDVC GHSFKQHSSL TQHQRIHTGE KPYKCNQCGK AFSLRSYLII HQRIHSGEKA YECSECGKAF NQSSALIRHR KIHTGEKACK CNECGKAFSQ SSYLIIHQRI HTGEKPYECN ECGKTFSQSS KLIRHQRIHT GERPYECNEC GKAFRQSSEL ITHQRIHSGE KPYECSECGK AFSLSSNLIR HQRIHSGEEP YQCNECGKTF KRSSALVQHQ RIHSGDEAYI CNECGKAFRH RSVLMRHQRV HTIK |
| 分子量 | 61.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF397蛋白的参考文献示例(注：因文献数据库访问限制，以下为演示性示例，建议通过PubMed或Google Scholar获取最新研究)：
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1. **文献名称**：*Cloning and Functional Characterization of Human ZNF397 as a Transcriptional Regulator*
**作者**：Zhang Y, et al.
**摘要**：该研究报道了ZNF397的基因克隆及其重组蛋白在哺乳动物细胞中的表达，发现其通过结合特定DNA序列调控下游基因转录，提示其在细胞分化和癌症中的潜在作用。
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2. **文献名称**：*Structural Insights into the Zinc Finger Domains of ZNF397 and Their Interaction with DNA*
**作者**：Lee S, Kim JH.
**摘要**：通过X射线晶体学解析了ZNF397蛋白的锌指结构域三维结构，揭示了其与DNA结合的分子机制，为设计靶向小分子提供了结构基础。
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3. **文献名称**：*ZNF397 Modulates Epigenetic Silencing in Triple-Negative Breast Cancer*
**作者**：Wang X, et al.
**摘要**：研究发现重组ZNF397蛋白与组蛋白去乙酰化酶(HDACs)相互作用，参与表观遗传调控，可能成为乳腺癌治疗的潜在靶点。
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**建议**：以上为参考示例，实际文献请通过学术数据库查询关键词“ZNF397”、“recombinant ZNF397 protein”或结合具体研究领域(如癌症、表观遗传学)获取近期研究。
Recombinant human ZNF397 protein is a genetically engineered form of the zinc finger protein 397 (ZNF397), encoded by the *ZNF397* gene in humans. As a member of the zinc finger protein family, ZNF397 contains multiple C2H2-type zinc finger domains, which are critical for DNA binding and protein-protein interactions. Zinc finger proteins are broadly involved in transcriptional regulation, chromatin remodeling, and epigenetic modifications, often acting as transcription factors or co-regulators. ZNF397 has been implicated in transcriptional repression and may participate in chromatin-associated complexes, potentially interacting with histone deacetylases (HDACs) to modulate gene expression.
Studies suggest its role in cellular processes such as proliferation, differentiation, and stress responses, though its precise biological functions remain under investigation. Recombinant ZNF397 is typically expressed in *E. coli* or mammalian cell systems, purified via affinity tags (e.g., His-tag), and used to study its molecular interactions, enzymatic activities, or structural properties *in vitro*. Its recombinant production enables research into mechanisms underlying diseases linked to ZNF397 dysregulation, including cancer and neurological disorders. Current applications span protein-DNA interaction assays, functional genomics, and drug discovery targeting zinc finger-mediated pathways. Further characterization of ZNF397 may uncover novel therapeutic strategies or diagnostic biomarkers.
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