| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF624 |
| Uniprot No | Q9P2J8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-739 aa |
| 活性数据 | MEPKPATKKATRTKAISEDLSQEAILEKLTENGLWDSRMEGLWKWNDRILRLQNNQENHLSQRIIPLKKTPTSQRGFRFESILIPEPGIATEELHSRCQTQEENFTENLNLITDTHLGKIICKEMKGSKAIRQTSELTLGKKSNNKEKPYKCSTCEKAFHYRSLLIQHQRTHTKEKPYECNECGKTFSQPSYLSQHKKIHTGEKPYKCNECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGEKPYKCDDCGKAFRNKSYLSVHQKTHTEEKPYQCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECNECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLTVHHRMHTGEKPYKCTECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYKCYDCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHTGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYKCEECGKAFRTNSDFTVHLRMHTGEKPYKCNECGKAFRSSSSLTVHQRIHQRETQLI |
| 分子量 | 112 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3条与重组人ZNF624蛋白相关的文献示例(根据公开信息模拟概括，具体文献需通过数据库验证)：
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1. **文献名称**: *ZNF624 as a Novel Transcriptional Repressor in Cell Proliferation Regulation*
**作者**: Li X, Wang Y, Zhang Q.
**摘要**: 本文首次报道ZNF624蛋白通过结合特定DNA序列抑制靶基因(如细胞周期相关基因)转录，体外重组实验表明其锌指结构域在抑制肺癌细胞增殖中起关键作用。
2. **文献名称**: *Structural analysis of recombinant human ZNF624 reveals its DNA-binding specificity*
**作者**: Park S, Kim H, Lee J.
**摘要**: 通过X射线晶体学解析重组ZNF624蛋白结构，发现其C端锌指模体优先识别富含GC的启动子区域，为研究其在基因调控网络中的作用提供结构基础。
3. **文献名称**: *Dysregulation of ZNF624 in hepatocellular carcinoma and its interaction with p53 pathway*
**作者**: Chen R, Zhou T, Xu L.
**摘要**: 研究显示，肝癌组织中ZNF624表达显著下调，体外重组蛋白实验证实其通过稳定p53蛋白抑制肿瘤生长，提示其可能作为癌症治疗新靶点。
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**注**：以上为模拟案例，实际文献需通过PubMed/Google Scholar检索关键词"ZNF624"或"Zinc Finger Protein 624"获取。近期研究(2020年后)可能涉及其在肿瘤或干细胞分化中的功能机制。
Zinc Finger Protein 624 (ZNF624) is a member of the zinc finger protein family, characterized by conserved Cys₂His₂ (C2H2)-type zinc finger domains that mediate sequence-specific DNA binding. These proteins are broadly involved in transcriptional regulation, chromatin remodeling, and cellular differentiation. ZNF624. located on human chromosome 17q21.2. encodes a nuclear protein predicted to function as a transcription factor, though its precise biological roles remain understudied. Current research links zinc finger proteins to developmental processes, cancer, and neurological disorders, but ZNF624's exact physiological or pathological significance is still emerging.
Recombinant ZNF624 protein is engineered in vitro, typically via bacterial or mammalian expression systems, to enable functional studies. Its recombinant form allows researchers to investigate DNA-binding specificity, protein-protein interactions, and regulatory mechanisms in gene expression. Structural studies using recombinant ZNF624 may clarify its zinc finger domain architecture and target gene motifs. While preliminary data suggest potential roles in cellular stress responses or differentiation pathways, comprehensive mechanistic insights are lacking.
The protein’s exploration holds promise for understanding transcriptional networks in development or disease, particularly cancers where zinc finger proteins often exhibit dysregulation. Further studies are required to map its interactome, validate target genes, and assess therapeutic relevance.
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