| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF764 |
| Uniprot No | Q96H86 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-408 aa |
| 活性数据 | MAPPLAPLPPRDPNGAGPEWREPGAVSFADVAVYFCREEWGCLRPAQRALYRDVMRETYGHLSALGIGGNKPALISWVEEEAELWGPAAQDPEVAKCQTQTDPADSRNKKKERQREGTGALEKPDPVAAGSPGLKSPQAPSAGPPYGWEQLSKAPHRGRPSLCAHPPVPRADQRHGCYVCGKSFAWRSTLVEHVYSHTGEKPFHCTDCGKGFGHASSLSKHRAIHRGERPHRCLECGRAFTQRSALTSHLRVHTGEKPYGCADCGRRFSQSSALYQHRRVHSGETPFPCPDCGRAFAYPSDLRRHVRTHTGEKPYPCPDCGRCFRQSSEMAVHRRTHSGEKPYPCPQCGRRFGQKSAVAKHQWVHRPGAGGHRGRVAGRLSVTLTPGHGDLDPPVGFQLYPEIFQECG |
| 分子量 | 71.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为模拟的关于重组人ZNF764蛋白的参考文献示例(具体文献需通过学术数据库核实)：
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1. **标题**：ZNF764 modulates glucocorticoid receptor transcriptional activity via recruitment of chromatin modifiers
**作者**：Smith A, et al.
**摘要**：本研究揭示了ZNF764通过与糖皮质激素受体(GR)相互作用，招募组蛋白去乙酰化酶(HDACs)复合物，抑制GR靶基因的过度激活，从而在炎症和代谢调控中起关键作用，为重组ZNF764蛋白的功能研究提供理论基础。(2021. *Cell Rep*)
2. **标题**：Structural analysis of recombinant human ZNF764 reveals zinc finger-dependent DNA binding specificity
**作者**：Chen L, et al.
**摘要**：通过体外表达纯化重组人ZNF764蛋白，解析其晶体结构，发现其C2H2型锌指结构域特异性识别DNA的调控序列，为设计基于ZNF764的基因编辑工具奠定结构基础。(2020. *Nucleic Acids Res*)
3. **标题**：ZNF764 overexpression suppresses breast cancer cell proliferation by downregulating oncogenic metabolic pathways
**作者**：Wang Y, et al.
**摘要**：利用重组ZNF764蛋白处理乳腺癌细胞，发现其通过抑制糖酵解关键基因(如HK2、LDHA)的转录，阻滞肿瘤细胞增殖，提示ZNF764在癌症治疗中的潜在应用价值。(2022. *Oncogene*)
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注：以上为基于ZNF764可能功能(转录调控、结构解析、疾病关联)的模拟文献。实际文献需查询PubMed、Web of Science等平台，关键词“ZNF764”或“Zinc Finger Protein 764”。
Zinc finger protein 764 (ZNF764) is a member of the zinc finger protein family, characterized by conserved Cys₂His₂ (C2H2)-type zinc finger domains that mediate sequence-specific DNA binding or protein-protein interactions. As a transcription factor, ZNF764 plays roles in gene regulation, particularly in pathways related to cell differentiation, proliferation, and apoptosis. It is implicated in modulating the transcriptional activity of nuclear receptors, such as glucocorticoid receptor (GR), estrogen receptor (ER), and androgen receptor (AR), by acting as a co-regulator or through direct interaction with response elements.
Studies suggest ZNF764 may influence cancer progression, with altered expression observed in malignancies like breast and prostate cancer. Its regulatory functions extend to chromatin remodeling and epigenetic modulation, often involving partnerships with histone deacetylases (HDACs) or methyltransferases. Additionally, ZNF764 interacts with proteins in the p53 signaling pathway, linking it to stress responses and apoptosis.
Recombinant human ZNF764 protein, produced via bacterial or mammalian expression systems, is widely used in functional studies to dissect its molecular mechanisms. Research tools, including purified ZNF764. antibodies, and knockdown models, have facilitated insights into its role in development, homeostasis, and disease. Despite progress, its precise physiological targets and tissue-specific functions remain under investigation, highlighting its potential as a therapeutic target or biomarker in oncology and endocrine disorders.
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