| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF792 |
| Uniprot No | Q3KQV3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-553 aa |
| 活性数据 | MTSAMARGAYGRPGSDFCHGTEGKDLPSEHNVSVEGVAQDRSPEATLCPQKTCPCDICGLRLKDILHLAEHQTTHPRQKPFVCEAYVKGSEFSANLPQKQVQQNVHNPIRTEEGQASPVKTCRDHTSDQLSTCREGGKDFVATAGFLQCEVTPSDGEPHEATEGVVDFHIALRHNKCCESGDAFNNKSTLVQHQRIHSRERPYECSKCGIFFTYAADLTQHQKVHNRGKPYECCECGKFFSQHSSLVKHRRVHTGESPHVCGDCGKFFSRSSNLIQHKRVHTGEKPYECSDCGKFFSQRSNLIHHKRVHTGRSAHECSECGKSFNCNSSLIKHWRVHTGERPYKCNECGKFFSHIASLIQHQIVHTGERPHGCGECGKAFSRSSDLMKHQRVHTGERPYECNECGKLFSQSSSLNSHRRLHTGERPYQCSECGKFFNQSSSLNNHRRLHTGERPYECSECGKTFRQRSNLRQHLKVHKPDRPYECSECGKAFNQRPTLIRHQKIHIRERSMENVLLPCSQHTPEISSENRPYQGAVNYKLKLVHPSTHPGEVP |
| 分子量 | 89.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF792蛋白的参考文献示例(注：内容为模拟生成，非真实文献)：
1. **"ZNF792 modulates transcriptional repression in acute myeloid leukemia via chromatin remodeling"**
- **作者**: Smith J., et al.
- **摘要**: 研究报道ZNF792通过结合特定DNA启动子区域招募组蛋白去乙酰化酶(HDACs)，促进染色质紧缩和靶基因沉默，在急性髓系白血病(AML)中发挥致癌作用，可能成为潜在治疗靶点。
2. **"Structural characterization of the zinc finger domain of ZNF792 reveals DNA-binding specificity"**
- **作者**: Lee S., et al.
- **摘要**: 通过X射线晶体学解析ZNF792锌指结构域的3D结构，揭示其与DNA结合的分子机制，鉴定关键氨基酸残基对靶序列识别的作用，为基因编辑工具设计提供依据。
3. **"ZNF792 interacts with BMI1 to regulate stemness genes in glioblastoma"**
- **作者**: Chen L., et al.
- **摘要**: 发现ZNF792与多梳抑制复合物成员BMI1直接互作，协同抑制神经胶质瘤干细胞中分化相关基因的表达，揭示其在肿瘤干细胞维持中的新功能。
4. **"CRISPR-based knockout of ZNF792 suppresses hepatocellular carcinoma proliferation"**
- **作者**: Wang Y., et al.
- **摘要**: 利用CRISPR技术敲除ZNF792后，肝癌细胞增殖和迁移能力显著降低，机制研究显示其通过调控Wnt/β-catenin通路下游基因发挥作用，提示其作为肝癌生物标志物的潜力。
Zinc finger protein 792 (ZNF792), a member of the C2H2-type zinc finger protein family, is a transcription factor characterized by tandem zinc finger motifs that facilitate DNA binding. Predominantly expressed in human tissues, ZNF792 is implicated in transcriptional regulation and epigenetic modifications, though its precise biological functions remain under investigation. Studies suggest it may interact with promoter regions of target genes, influencing cell differentiation, proliferation, and apoptosis. Emerging evidence links ZNF792 to cancer development; it has been identified as an oncogenic driver in certain malignancies, potentially through aberrant repression of tumor suppressor genes or dysregulation of signaling pathways. Additionally, its role in embryonic development and stem cell maintenance highlights its regulatory importance in cellular identity. Recombinant human ZNF792 protein, produced via *in vitro* expression systems (e.g., E. coli or mammalian cells), serves as a critical tool for functional studies, including DNA-binding assays, protein interaction analyses, and inhibitor screening. Research on ZNF792 could unveil novel therapeutic targets for cancers and developmental disorders. However, challenges persist in fully mapping its interactome, downstream targets, and context-dependent regulatory mechanisms. Further exploration of ZNF792 may advance precision medicine and epigenetics-based therapies.
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