| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF771 |
| Uniprot No | Q7L3S4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-275 aa |
| 活性数据 | MDNKEVPGEAPAPSADPARPHACPDCGRAFARRSTLAKHARTHTGERPFGCTECGRRFSQKSALTKHGRTHTGERPYECPECDKRFSAASNLRQHRRRHTGEKPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRAFGGSSCLARHRRTHTGERPYACADCGTRFAQSSALAKHRRVHTGEKPHRCAVCGRRFGHRSNLAEHARTHTGERPYPCAECGRRFRLSSHFIRHRRAHMRRRLYICAGCGRDFKLPPGATAATATERCPECEGS |
| 分子量 | 57.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是 **模拟示例** 的关于重组人ZNF771蛋白的参考文献(非真实文献，仅供格式参考)：
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1. **文献名称**: *"Cloning and Functional Characterization of the Zinc Finger Protein ZNF771"*
**作者**: Smith JL, et al.
**摘要**: 本研究成功克隆并表达了人源ZNF771重组蛋白，验证其锌指结构域与DNA结合活性，并发现其在体外可调控靶基因启动子区域的转录活性。
2. **文献名称**: *"ZNF771 Regulates Neuronal Differentiation via Epigenetic Modifications"*
**作者**: Chen R, Wang H.
**摘要**: 通过重组ZNF771蛋白的功能实验，揭示了其与组蛋白脱乙酰酶(HDACs)相互作用，参与神经细胞分化的表观遗传调控机制。
3. **文献名称**: *"Structural Insights into ZNF771 Protein: Implications for Protein Stability and Interaction Networks"*
**作者**: Gonzalez M, et al.
**摘要**: 利用X射线晶体学解析了重组ZNF771蛋白的锌指结构域三维结构，并预测其可能的蛋白质互作界面，为功能研究提供结构基础。
4. **文献名称**: *"ZNF771 Overexpression in Cancer: Role in Tumorigenesis and Drug Resistance"*
**作者**: Kim S, et al.
**摘要**: 发现ZNF771在多种癌症中高表达，并证实重组蛋白的过量表达可通过激活Wnt/β-catenin通路增强肿瘤细胞的耐药性。
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**注意**：以上为假设性文献示例，实际研究中请通过 **PubMed/Google Scholar** 检索真实文献(关键词：ZNF771 recombinant protein, function, structure)。
Zinc finger protein 771 (ZNF771) is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which represents one of the largest groups of transcriptional regulators in humans. As a C2H2-type zinc finger protein, ZNF771 contains multiple tandem zinc finger motifs that enable sequence-specific DNA binding, potentially targeting gene promoters or regulatory regions to modulate transcriptional activity. It is encoded by the ZNF771 gene located on chromosome 12q13.13. a region associated with several neurological and developmental disorders.
Though functional studies on ZNF771 remain limited, emerging evidence suggests its involvement in chromatin remodeling and epigenetic regulation, likely through interactions with repressor complexes mediated by its KRAB domain. Expression profiling shows tissue-specific patterns, with higher abundance in brain and testis, implying roles in neurodevelopment or germ cell regulation. Recent links to diseases include its identification as a tumor suppressor in clear cell renal cell carcinoma (ccRCC), where promoter hypermethylation silences ZNF771 expression, correlating with poor prognosis. Additionally, genomic variations near ZNF771 have been associated with neuropsychiatric conditions like schizophrenia.
As a recombinant protein, ZNF771 is utilized to explore DNA-protein interactions, transcriptional mechanisms, and disease-related pathways, offering potential as a diagnostic biomarker or therapeutic target. Ongoing research aims to clarify its physiological targets and pathological contributions across tissues.
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