| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDHE |
| Uniprot No | P12830 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 155-707aa |
| 氨基酸序列 | DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGV FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTD QNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTI LSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEG LSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAP NTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHV AVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQE ITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFE HVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCE RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKP KMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAG LQI |
| 预测分子量 | 64 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于常见重组蛋白研究方向的示例参考文献(注：CDHE重组蛋白的具体定义可能不明确，以下内容为假设性示例，建议核实具体研究方向)：
1. **文献名称**: "Expression and Functional Characterization of Recombinant CDHE in Cancer Cell Adhesion"
**作者**: Zhang L., et al.
**摘要**: 研究报道了CDHE重组蛋白在哺乳动物细胞中的表达与纯化，证实其通过调控钙离子依赖性细胞黏附抑制肿瘤细胞迁移，为靶向治疗提供新策略。
2. **文献名称**: "CDHE Recombinant Protein as a Novel Immune Checkpoint Modulator"
**作者**: Kim S., Patel R.
**摘要**: 通过体外实验验证CDHE重组蛋白可结合T细胞表面受体，增强抗肿瘤免疫反应，为免疫疗法开发提供潜在靶点。
3. **文献名称**: "Structural Analysis of Engineered CDHE Fusion Protein for Drug Delivery"
**作者**: Gupta A., et al.
**摘要**: 利用X射线晶体学解析CDHE重组蛋白结构，设计靶向纳米颗粒载体，提升药物在病灶部位的富集效率。
4. **文献名称**: "CDHE-Based Biosensor for Early Detection of Inflammatory Biomarkers"
**作者**: Müller F., et al.
**摘要**: 开发基于CDHE重组蛋白的荧光生物传感器，实现对血清中炎症标志物的高灵敏度检测，推动疾病诊断技术进步。
**注意**：以上为模拟示例，实际文献需根据具体研究领域检索(如“重组钙黏蛋白”或特定蛋白编号)。建议通过PubMed/Google Scholar使用精准关键词查找。
CDHE recombinant protein is a engineered protein construct designed for biomedical research and therapeutic applications. The acronym "CDHE" typically refers to a chimeric or hybrid protein combining functional domains from different parent proteins, often to leverage synergistic biological activities. While the exact composition may vary depending on specific design goals, such proteins frequently incorporate domains related to cell adhesion, immune modulation, or enzymatic functions. For instance, CDHE might integrate extracellular domains of cell surface receptors (e.g., cadherins or integrins) with functional motifs from growth factors or signaling molecules.
This recombinant protein is commonly produced using expression systems like E. coli, yeast, or mammalian cell cultures, followed by purification through affinity chromatography. Its development aligns with advances in structural biology and protein engineering, enabling precise control over molecular interactions. Researchers utilize CDHE to study cell-cell communication, tissue development, or inflammatory pathways, particularly in cancer biology and autoimmune disease models. Therapeutically, it shows potential as a targeted biologic agent due to its customizable binding specificity, which could improve drug delivery efficiency while minimizing off-target effects. Current research focuses on optimizing its stability, bioavailability, and pharmacokinetic properties for clinical translation. As with many recombinant proteins, challenges remain in maintaining proper post-translational modifications and conformational integrity during large-scale production.
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