首页 / 产品 / 蛋白 / 细胞因子、趋化因子与生长因子
| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | INHbB |
| Uniprot No | P09529 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-407aa |
| 氨基酸序列 | MDGLPGRALGAACLLLLAAGWLGPEAWGSPTPPPTPAAQPPPPPPGSPGG SQDTCTSCGGFRRPEELGRVDGDFLEAVKRHILSRLQMRGRPNITHAVPK AAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETD GLASSRVRLYFFISNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVK VYFQEQGHGDRWNMVEKRVDLKRSGWHTFPLTEAIQALFERGERRLNLDV QCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRT NLCCRQQFFIDFRLIGWNDWIIAPTSYYGNYCEGSCPAYLAGVPGSASSF HTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMI VEECGCA |
| 预测分子量 | 45,1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于INHbB(抑制素β B亚基)重组蛋白的模拟参考文献示例，供参考：
---
1. **标题**: *Recombinant Human Inhibin β B Subunit Production in E. coli and Its Role in Ovarian Function*
**作者**: Smith JL, et al.
**摘要**: 本研究利用大肠杆菌系统成功表达并纯化了重组人INHbB蛋白，验证了其生物活性。通过体外实验证实，重组INHbB可调节颗粒细胞中FSH(促卵泡激素)的分泌，为研究卵巢生理机制提供了工具。
2. **标题**: *Structural Characterization of Inhibin β B and Its Interaction with Activin Receptors*
**作者**: Chen R, et al.
**摘要**: 采用X射线晶体学解析了重组INHbB蛋白的三维结构，揭示了其与激活素II型受体的结合模式。研究强调了INHbB在TGF-β信号通路中的竞争性抑制作用，为靶向治疗提供了结构基础。
3. **标题**: *Development of a Mammalian Cell Expression System for High-Yield INHbB Production*
**作者**: Gupta S, et al.
**摘要**: 通过优化HEK293细胞表达条件，实现了重组INHbB的高效分泌表达，产量较传统系统提升5倍。纯化蛋白在动物模型中显示出调节睾丸功能的作用，支持其在生殖疾病治疗中的应用潜力。
4. **标题**: *INHbB Recombinant Protein Attenuates Fibrosis in a Murine Liver Injury Model*
**作者**: Tanaka K, et al.
**摘要**: 研究发现，外源性重组INHbB可通过抑制肝星状细胞活化，显著减轻小鼠肝纤维化程度。机制研究表明其作用与阻断TGF-β/Smad通路相关，提示INHbB作为抗纤维化药物的可能性。
---
**注**：以上文献为示例性内容，实际引用时需以真实出版物为准。建议通过PubMed、Web of Science等平台以关键词“INHbB recombinant protein”、“Inhibin beta B subunit”等检索最新研究。
Inhibin β B (INHβB), a subunit of the inhibin/activin protein family, plays a critical role in regulating cellular processes such as proliferation, differentiation, and apoptosis. It belongs to the transforming growth factor-beta (TGF-β) superfamily and forms heterodimers (inhibins) or homodimers (activins) with other subunits. Specifically, INHβB pairs with an α subunit (INHα) to form inhibin B, which suppresses follicle-stimulating hormone (FSH) secretion, or dimerizes with another β subunit (e.g., INHβA) to form activin B, enhancing FSH release and modulating reproductive functions.
Recombinant INHβB protein is engineered using expression systems like mammalian cells or *E. coli* to ensure proper folding and post-translational modifications. Its production enables detailed study of signaling pathways, particularly the Smad-dependent cascade activated by binding to type I/II serine-threonine kinase receptors. Dysregulation of INHβB is linked to reproductive disorders, cancers, and fibrosis, making it a target for therapeutic research.
In research, recombinant INHβB aids in exploring its dual role in inhibiting or stimulating FSH, depending on dimerization partners, and its context-dependent effects in tissues. It also serves as a tool for developing assays or therapies targeting activin/inhibin imbalances. Studies highlight its potential in treating conditions like polycystic ovary syndrome (PCOS) or counteracting muscle wasting via antagonism of excessive activin signaling. Overall, recombinant INHβB remains pivotal in unraveling TGF-β family biology and its clinical applications.
×
